Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, USA.
Ann Pharmacother. 2012 Feb;46(2):192-9. doi: 10.1345/aph.1Q555. Epub 2012 Jan 31.
Cardiovascular events associated with energy drink consumption have been reported, but few data exist to delineate the hemodynamic effects of energy drinks.
To compare the effects of an energy drink versus caffeine supplementation on blood pressure (BP) indices as measured by 24-hour ambulatory BP monitoring (ABPM).
Healthy, nonsmoking, normotensive volunteers (aged 18-45 years) taking no medications were enrolled in a single-center, open-label, 2-period crossover pilot study. During each study period, subjects received either an energy drink (Red Bull Energy Drink, each dose containing 80 mg of caffeine and 1000 mg of taurine in an 8.3-oz serving) or a control (compounded caffeine solution, each dose containing 80 mg of caffeine solution in 8 oz of bottled water) at 0800, 1100, 1500, and 1900 hours and underwent 24-hour ABPM. The study periods were separated by a washout period (4-30 days). Mean 24-hour, daytime, and nighttime systolic (SBP), diastolic (DBP), and mean arterial (MAP) BP; BP load; and percent nocturnal dipping were compared between study periods.
Nine subjects (5 females, mean [SD] age 27.7 [5.0] years) completed the study. Mean 24-hour SBP (123.2 vs 117.4 mm Hg, p = 0.04), DBP (73.6 vs 68.2 mm Hg, p = 0.02), and MAP (90.1 vs 84.8 mm Hg, p = 0.03) were significantly higher during energy drink supplementation versus caffeine supplementation. Daytime DBP (77.0 vs 72.0 mm Hg, p = 0.04) also was significantly higher with the energy drink versus caffeine supplementation. Trends in higher daytime SBP (127.0 vs 121.9 mm Hg, p = 0.05) and MAP (93.6 vs 88.6 mm Hg, p = 0.05) were recorded with energy drink supplementation versus caffeine supplementation. Nighttime SBP and DBP loads were significantly higher with the energy drink, but nocturnal dipping did not differ significantly between study periods.
Single-day energy drink supplementation increased mean 24-hour and daytime BP compared to caffeine control in this pilot study. Additional research is warranted to better understand the hemodynamic effects of energy drink consumption.
已有报道称，能量饮料的摄入与心血管事件有关，但很少有数据可以描述能量饮料对血流动力学的影响。
通过 24 小时动态血压监测（ABPM）比较能量饮料与咖啡因补充对血压（BP）指数的影响。
本研究纳入了健康、不吸烟、血压正常的志愿者（年龄 18-45 岁），他们未服用任何药物。这些志愿者参与了一项单中心、开放标签、2 期交叉先导研究。在每个研究期间，受试者分别在 0800、1100、1500 和 1900 小时接受能量饮料（红牛能量饮料，每份含 80 毫克咖啡因和 1000 毫克牛磺酸，每份 8.3 盎司）或对照物（复合咖啡因溶液，每份含 80 毫克咖啡因溶液，8 盎司瓶装水），并进行 24 小时 ABPM。研究期间通过洗脱期（4-30 天）隔开。比较研究期间的 24 小时平均、白天和夜间收缩压（SBP）、舒张压（DBP）和平均动脉压（MAP）、BP 负荷和夜间血压下降百分比。
9 名受试者（5 名女性，平均年龄 27.7 [5.0] 岁）完成了该研究。与咖啡因补充相比，能量饮料补充时的 24 小时平均 SBP（123.2 对 117.4mmHg，p=0.04）、DBP（73.6 对 68.2mmHg，p=0.02）和 MAP（90.1 对 84.8mmHg，p=0.03）明显更高。与咖啡因补充相比，能量饮料补充时日间 DBP（77.0 对 72.0mmHg，p=0.04）也明显更高。记录到日间 SBP（127.0 对 121.9mmHg，p=0.05）和 MAP（93.6 对 88.6mmHg，p=0.05）的升高趋势，且这些趋势在能量饮料补充时更为明显。与咖啡因补充相比，夜间 SBP 和 DBP 负荷明显更高，但夜间血压下降百分比在两个研究期间无显著差异。
在本先导研究中，与咖啡因对照相比，能量饮料单次补充可增加 24 小时平均和日间血压。需要进一步研究以更好地了解能量饮料消费对血流动力学的影响。
