从骨髓到动脉壁：内皮祖细胞的故事仍在继续。
From bone marrow to the arterial wall: the ongoing tale of endothelial progenitor cells.
作者信息
Leone Antonio Maria, Valgimigli Marco, Giannico Maria Benedetta, Zaccone Vincenzo, Perfetti Matteo, D'Amario Domenico, Rebuzzi Antonio Giuseppe, Crea Filippo
机构信息
Institute of Cardiology, Catholic University of the Sacred Heart, Largo A. Gemelli 8, 00168 Rome, Italy.
出版信息
Eur Heart J. 2009 Apr;30(8):890-9. doi: 10.1093/eurheartj/ehp078. Epub 2009 Mar 19.
Several physiological and pathophysiological stimuli or drugs modulate endothelial progenitor cell (EPC) mobilization. Moreover, levels of circulating EPCs predict cardiovascular risk and left ventricular remodelling after myocardial infarction. Nevertheless, our understanding in this field is complicated by lack of an unequivocal definition of EPCs, thus limiting their clinical applications. This review summarizes current knowledge and uncertainties on EPC characterization and mobilization in the attempt to define their role in the management of cardiovascular diseases.
多种生理和病理生理刺激或药物可调节内皮祖细胞（EPC）的动员。此外，循环EPC的水平可预测心肌梗死后的心血管风险和左心室重构。然而，由于缺乏对EPC的明确界定，我们对该领域的理解变得复杂，从而限制了它们的临床应用。本综述总结了关于EPC特征和动员的现有知识及不确定性，试图明确它们在心血管疾病管理中的作用。
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