低表达的人类微小RNA基因进化迅速。
Lowly expressed human microRNA genes evolve rapidly.
作者信息
Liang Han, Li Wen-Hsiung
出版信息
Mol Biol Evol. 2009 Jun;26(6):1195-8. doi: 10.1093/molbev/msp053. Epub 2009 Mar 19.
Abstract
To study the evolution of human microRNAs (miRNAs), we examined nucleotide variation in humans, sequence divergence between species, and genomic clustering patterns for miRNAs with different expression levels. We found that expression level is a major indicator of the rate of evolution and that approximately 30% of currently annotated human miRNA genes are almost free of selective pressure.
摘要
为了研究人类微小RNA（miRNA）的进化，我们检测了人类中的核苷酸变异、物种间的序列差异以及不同表达水平的miRNA的基因组聚类模式。我们发现表达水平是进化速率的主要指标，并且目前注释的人类miRNA基因中约30%几乎没有受到选择压力。
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