褪黑素对腹腔镜胆囊切除术后睡眠质量的影响：一项随机、安慰剂对照试验。
The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial.
作者信息
Gögenur Ismail, Kücükakin Bülent, Bisgaard Thue, Kristiansen Viggo, Hjortsø Niels-Christian, Skene Debra J, Rosenberg Jacob
机构信息
Department of Surgical Gastroenterology D, University of Copenhagen, Gentofte Hospital, Niels Andersens Vej 65, DK-2900 Hellerup, Denmark.
出版信息
Anesth Analg. 2009 Apr;108(4):1152-6. doi: 10.1213/ane.0b013e31819a6cf0.
BACKGROUND
In this study, we investigated whether melatonin administration could improve postoperative subjective sleep quality and reduce discomfort.
METHODS
One hundred twenty-one patients scheduled for elective ambulatory laparoscopic cholecystectomy were randomized to oral 5 mg melatonin (n = 60) or placebo (n = 61) for 3 nights after surgery. Subjective sleep quality, sleep duration, sleep timing, and subjective discomfort (fatigue, general well-being, and pain) were measured.
RESULTS
Sleep latency was significantly reduced in the melatonin group (mean [sd] 14 min [18]) compared with placebo (28 min [41]) on the first postoperative night (P = 0.015). The rest of the measured outcome variables did not differ between groups.
CONCLUSIONS
Melatonin did not improve subjective sleep quality or discomfort compared with placebo after laparoscopic cholecystectomy.
背景
在本研究中，我们调查了褪黑素给药是否能改善术后主观睡眠质量并减轻不适。
方法
121例计划行择期门诊腹腔镜胆囊切除术的患者被随机分为两组，术后连续3晚口服5毫克褪黑素（n = 60）或安慰剂（n = 61）。测量主观睡眠质量、睡眠时间、睡眠时间以及主观不适（疲劳、总体健康状况和疼痛）。
结果
与安慰剂组（28分钟[41]）相比，褪黑素组在术后第一晚的睡眠潜伏期显著缩短（均值[标准差]14分钟[18]）（P = 0.015）。其余测量的结果变量在两组之间无差异。
结论
与安慰剂相比，腹腔镜胆囊切除术后褪黑素并未改善主观睡眠质量或不适。
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