Aldred Sarah, Rohalu Manjit, Edwards Kate, Burns Victoria
School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, UK.
J Aging Phys Act. 2009 Jan;17(1):77-88. doi: 10.1123/japa.17.1.77.
Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are hormones produced by the adrenal cortex that decline in concentration with age. Decreased DHEA levels are associated with age-related disease and oxidative stress but might be increased in younger adults by exercise. Studies are presented assessing the response of DHEA and DHEAS to varied-intensity exercise in older age. DHEA increased significantly in young adults (14.5 +/- 6.1 ng/ml rising to 21.1 +/- 7.5 ng/ml; p < .01), whereas DHEAS decreased significantly (2.56 +/- 1.11 microg/ml falling to 1.90 +/- 0.8 microg/ml; p < .05), after submaximal exercise. DHEA and DHEAS levels were significantly lower in older adults than in younger adults (p < .01), and there was no observed response of either hormone to exercise in older adults. Lipoprotein protein carbonylation is presented as a measure of oxidative status and significantly decreased in younger adults postexercise. Participants with higher DHEA postexercise had lower LDL protein carbonyl concentrations (Pearson's coefficient -.409, p < .05).
脱氢表雄酮（DHEA）及其硫酸盐（DHEAS）是由肾上腺皮质产生的激素，其浓度会随着年龄的增长而下降。DHEA水平降低与年龄相关疾病和氧化应激有关，但在年轻人中，运动可能会使其水平升高。本文呈现了一些研究，评估了DHEA和DHEAS对老年人不同强度运动的反应。在进行次最大运动后，年轻人的DHEA显著增加（从14.5±6.1纳克/毫升升至21.1±7.5纳克/毫升；p<.01），而DHEAS则显著降低（从2.56±1.11微克/毫升降至1.90±0.8微克/毫升；p<.05）。老年人的DHEA和DHEAS水平显著低于年轻人（p<.01），且未观察到老年人的这两种激素对运动有反应。脂蛋白蛋白羰基化作为氧化状态的一种衡量指标，在年轻人运动后显著降低。运动后DHEA水平较高的参与者，其低密度脂蛋白蛋白羰基浓度较低（皮尔逊系数为-.409，p<.05）。
