Liu Da-Neng, Tian Shi-Kai
Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China.
Chemistry. 2009;15(18):4538-42. doi: 10.1002/chem.200900177.
Geometrical control: PPh(3) and methyl acrylate (or acrylamide) are able to mediate the one-pot Wittig reaction of aldehydes with alpha-halo carbonyl compounds for the synthesis of 1,2-disubstituted and trisubstituted alkenes in an excellent stereoselective fashion. Furthermore, the first one-pot, three-component reaction of aldehydes, alpha-halo acetates, and terminal alkenes has been developed in the presence of PPh(3) to produce trisubstituted alkenes with excellent E selectivity (see scheme).
三苯基膦（PPh(3)）与丙烯酸甲酯（或丙烯酰胺）能够介导醛与α-卤代羰基化合物的一锅法维蒂希反应，以优异的立体选择性合成1,2-二取代和三取代烯烃。此外，已开发出在三苯基膦（PPh(3)）存在下醛、α-卤代乙酸酯和末端烯烃的首个一锅法三组分反应，以优异的E选择性生成三取代烯烃（见方案）。
