Institute for Materials Chemistry and Engineering (IMCE), Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
Molecules. 2012 Sep 27;17(10):11469-83. doi: 10.3390/molecules171011469.
Silica gel was found to be an excellent medium for some useful organic transformations under organic solvent-free conditions, such as (1) the Friedel-Crafts-type nitration of arenes using commercial aqueous 69% nitric acid alone at room temperature, (2) one-pot Wittig-type olefination of aldehydes with activated organic halides in the presence of tributyl- or triphenylphosphine and Hunig's base, and (3) the Morita-Baylis-Hillman reaction of aldehydes with methyl acrylate. After the reactions, the desired products were easily obtained in good to excellent yields through simple manipulation.
硅胶被发现是一种在无有机溶剂条件下进行某些有用的有机转化的优良介质，例如：(1) 在室温下仅使用商业 69%的硝酸水溶液进行芳基的 Friedel-Crafts 型硝化；(2) 在三丁基或三苯基膦和 Hunig 碱的存在下，用活性有机卤化物一锅法进行 Wittig 型烯丙基化；(3) 用甲基丙烯酸甲酯进行 Morita-Baylis-Hillman 反应。反应后，通过简单的操作，很容易以良好到优异的收率获得所需产物。
