Sundarathiti Petchara, Ruananukul Narut, Channum Thanapot, Kitkunasathean Chusak, Mantay Aunthika, Thammasakulsiri Jadesadha, Sodsee Wanida
Department of Anesthesiology, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 2009 Mar;92(3):328-34.
Postoperative epidural analgesia (EA) and femoral nerve block (FNB) provided effective pain relief However, EA has common side effects such as nausea, vomiting, pruritus, dizziness, and hypotension. Some investigations found that those side effects were less in FNB than in EA. However the analgesic equivalent of both techniques have not been confirmed.
The authors compared continuous epidural infusion (CEI) with continuous femoral nerve block (CFNB) regarding the postoperative analgesic efficacy, side effects, postoperative knee rehabilitation, and hospital length of stay (LOS).
In this prospective, randomized controlled study, 61 ASA physical status I-III patients scheduled for elective unilateral total knee arthroplasty (TKA) under spinal anesthesia (SA) participated. The patients were allocated into two groups. In the ward, patients in Group I (CEI) were maintained by continuous infusion of 0.125% levobupivacaine with morphine 0.0125 mg/ml (4 ml/hr), Group II (CFNB) were maintained by 0.125% levobupivacaine (8 ml/hr).
Patients in the CFNB group, the VAS scores at PO6-12 hr and tramadol IV requirement were significantly greater than the CEI group (VAS: PO6 hr p-value = 0.001, PO12 hr p-value = 0.004). Patients in the CEI group experienced dizziness, pruritus, and PONV more than the CFNB group significantly. Patient satisfaction was greater with the CFNB group although postoperative knee rehabilitation and the hospital LOS were not different.
CFNB represents the optimal analgesia with fewer side effects and greater patient, satisfaction. The rehabilitation indices and duration of hospital stay are comparable in both groups.
术后硬膜外镇痛(EA)和股神经阻滞(FNB)均可有效缓解疼痛。然而,EA存在恶心、呕吐、瘙痒、头晕和低血压等常见副作用。一些研究发现,FNB的这些副作用比EA少。但两种技术的镇痛等效性尚未得到证实。
作者比较了持续硬膜外输注(CEI)和持续股神经阻滞(CFNB)在术后镇痛效果、副作用、术后膝关节康复及住院时间(LOS)方面的差异。
在这项前瞻性随机对照研究中,61例计划在脊髓麻醉(SA)下进行择期单侧全膝关节置换术(TKA)的ASA身体状况I-III级患者参与。患者被分为两组。在病房,I组(CEI)患者通过持续输注0.125%左旋布比卡因与0.0125mg/ml吗啡(4ml/小时)维持,II组(CFNB)患者通过0.125%左旋布比卡因(8ml/小时)维持。
CFNB组患者在术后6-12小时的视觉模拟评分(VAS)及曲马多静脉注射需求量显著高于CEI组(VAS:术后6小时p值=0.001,术后12小时p值=0.004)。CEI组患者出现头晕、瘙痒和术后恶心呕吐(PONV)的情况明显多于CFNB组。CFNB组患者满意度更高,尽管术后膝关节康复及住院时间无差异。
CFNB是副作用更少、患者满意度更高的最佳镇痛方法。两组的康复指标及住院时间相当。