镉离子和汞离子对ada基因转录的抑制作用。
Inhibitory effect of cadmium and mercury ions on transcription of the ada gene.
作者信息
Suzuki M, Takahashi K, Kawazoe Y, Sakumi K, Sekiguchi M
机构信息
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
出版信息
Biochem Biophys Res Commun. 1991 Sep 30;179(3):1517-21. doi: 10.1016/0006-291x(91)91744-w.
PMID:1930191
Abstract
The effect of Cd2+ and Hg2+ on transcription of the ada gene was examined using an in vitro system reconstituted with Ada protein and methylated DNA, together with their effect on methyltransferase activity of the Ada protein. Both Cd2+ and Hg2+ inhibited transcription of the ada gene over the doses which did not inhibit methyltransferase activity.
摘要
利用由Ada蛋白和甲基化DNA重构的体外系统，研究了Cd2+和Hg2+对ada基因转录的影响，以及它们对Ada蛋白甲基转移酶活性的影响。在不抑制甲基转移酶活性的剂量范围内，Cd2+和Hg2+均抑制ada基因的转录。
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