滤泡辅助性T细胞：谱系与定位
Follicular helper T cells: lineage and location.
作者信息
Fazilleau Nicolas, Mark Linda, McHeyzer-Williams Louise J, McHeyzer-Williams Michael G
机构信息
Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
Immunity. 2009 Mar 20;30(3):324-35. doi: 10.1016/j.immuni.2009.03.003.
Abstract
Follicular helper T (Tfh) cells are the class of effector T helper cells that regulates the step-wise development of antigen-specific B cell immunity in vivo. Deployment of CXCR5+ Tfh cells to B cell zones of lymphoid tissues and stable cognate interactions with B cells are central to the delivery of antigen-specific Tfh cell function. Here, we review recent advances that have helped to unravel distinctive elements of developmental programming for Tfh cells and unique effector Tfh cell functions focused on antigen-primed B cells. Understanding the regulatory functions of Tfh cells in the germinal center and the subsequent regulation of memory B cell responses to antigen recall represent the frontiers of this research area with the potential to alter fundamentally the design of future vaccines.
摘要
滤泡辅助性T（Tfh）细胞是一类效应性辅助性T细胞，可在体内调节抗原特异性B细胞免疫的逐步发展。将CXCR5 + Tfh细胞部署到淋巴组织的B细胞区并与B细胞进行稳定的同源相互作用，对于实现抗原特异性Tfh细胞功能至关重要。在此，我们综述了最近的进展，这些进展有助于揭示Tfh细胞发育编程的独特要素以及专注于抗原启动B细胞的独特效应性Tfh细胞功能。了解Tfh细胞在生发中心的调节功能以及随后对记忆B细胞对抗原回忆反应的调节，代表了该研究领域的前沿，有可能从根本上改变未来疫苗的设计。
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