Mao Hongmei, Lin Xin, Sun Yi
Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education) of the Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310029, China.
Institute for Immunology, School of Medicine, Tsinghua University, Beijing 100084, China.
Research (Wash D C). 2023 Dec 7;6:0283. doi: 10.34133/research.0283. eCollection 2023.
Neddylation plays a vital role in post-translational modification, intricately shaping the regulation of diverse biological processes, including those related to cellular immune responses. In fact, neddylation exerts control over both innate and adaptive immune systems via various mechanisms. Specifically, neddylation influences the function and survival of innate immune cells, activation of pattern recognition receptors and GMP-AMP synthase-stimulator of interferon genes pathways, as well as the release of various cytokines in innate immune reactions. Moreover, neddylation also governs the function and survival of antigen-presenting cells, which are crucial for initiating adaptive immune reactions. In addition, neddylation regulates T cell activation, proliferation, differentiation, survival, and their effector functions, thereby ensuring an appropriate adaptive immune response. In this review, we summarize the most recent findings in these aspects and delve into the connection between dysregulated neddylation events and immunological disorders, especially inflammatory diseases. Lastly, we propose future directions and potential treatments for these diseases by targeting neddylation.
Neddylation在翻译后修饰中起着至关重要的作用，它以复杂的方式塑造了包括细胞免疫反应相关过程在内的多种生物过程的调控。事实上，Neddylation通过多种机制对先天性和适应性免疫系统都发挥着控制作用。具体而言，Neddylation影响先天性免疫细胞的功能和存活、模式识别受体的激活以及干扰素基因途径的GMP-AMP合酶刺激物，以及先天性免疫反应中各种细胞因子的释放。此外，Neddylation还控制着抗原呈递细胞的功能和存活，而抗原呈递细胞对于启动适应性免疫反应至关重要。此外，Neddylation调节T细胞的激活、增殖、分化、存活及其效应功能，从而确保适当的适应性免疫反应。在本综述中，我们总结了这些方面的最新发现，并深入探讨了Neddylation事件失调与免疫紊乱，特别是炎症性疾病之间的联系。最后，我们提出了针对Neddylation的这些疾病的未来方向和潜在治疗方法。
