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利用牛心亚线粒体颗粒和大肠杆菌细胞色素bd末端氧化酶组装嵌合呼吸链。

Assembly of a chimeric respiratory chain from bovine heart submitochondrial particles and cytochrome bd terminal oxidase of Escherichia coli.

作者信息

Gavrikova Eleonora V, Grivennikova Vera G, Borisov Vitaliy B, Cecchini Gary, Vinogradov Andrei D

机构信息

Department of Biochemistry, School of Biology, Moscow State University, Moscow 119991, Russian Federation.

出版信息

FEBS Lett. 2009 Apr 17;583(8):1287-91. doi: 10.1016/j.febslet.2009.03.022. Epub 2009 Mar 20.

Abstract

Cytochrome bd is a terminal quinol oxidase in Escherichia coli. Mitochondrial respiration is inhibited at cytochrome bc(1) (complex III) by myxothiazol. Mixing purified cytochrome bd oxidase with myxothiazol-inhibited bovine heart submitochondrial particles (SMP) restores up to 50% of the original rotenone-sensitive NADH oxidase and succinate oxidase activities in the absence of exogenous ubiquinone analogs. Complex III bypassed respiration and is saturated at amounts of added cytochrome bd similar to that of other natural respiratory components in SMP. The cytochrome bd tightly binds to the mitochondrial membrane and operates as an intrinsic component of the chimeric respiratory chain.

摘要

细胞色素bd是大肠杆菌中的一种末端醌氧化酶。抗霉素A在细胞色素bc(1)(复合体III)处抑制线粒体呼吸。将纯化的细胞色素bd氧化酶与抗霉素A抑制的牛心亚线粒体颗粒(SMP)混合,在没有外源性泛醌类似物的情况下,可恢复高达50%的原始对鱼藤酮敏感的NADH氧化酶和琥珀酸氧化酶活性。复合体III绕过呼吸作用,并且在添加的细胞色素bd量与SMP中其他天然呼吸成分的量相似时达到饱和。细胞色素bd紧密结合在线粒体膜上,并作为嵌合呼吸链的内在成分发挥作用。

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