Anglin Deidre, Stanford Arielle D, Harkavy-Friedman Jill M, Goetz Raymond, Rosenfield Paul, Malaspina Dolores
Department of Psychology, The City College and The Graduate Center, City University of New York, United States.
Schizophr Res. 2009 May;110(1-3):24-7. doi: 10.1016/j.schres.2009.02.020. Epub 2009 Mar 21.
This study examined the relationship between having a family history of affective disorder and neuropsychological functioning and PANSS symptoms in schizophrenia patients falling into four exclusive family history groups (affective spectrum disorders, schizophrenia spectrum disorders, both, or neither). Schizophrenia patients with a family history of affective illness had the best performance on IQ tests and executive function measures. Symptoms showed fewer family history group differences. Schizophrenia patients with a family history of affective disorder may be a distinct subtype in the group of schizophrenias and may be biologically more similar to patients with serious affective disorder.
本研究调查了患有情感障碍家族史与四类互斥家族史组（情感谱系障碍、精神分裂症谱系障碍、两者皆有或两者皆无）的精神分裂症患者的神经心理功能及阳性和阴性症状量表（PANSS）症状之间的关系。有情感疾病家族史的精神分裂症患者在智商测试和执行功能测量方面表现最佳。症状在家族史组间差异较小。有情感障碍家族史的精神分裂症患者可能是精神分裂症群体中的一个独特亚型，并且在生物学上可能与患有严重情感障碍的患者更为相似。
