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儿童期髋关节肿瘤及肿瘤样病变:里佐利医院经验综述

Tumours and tumour-like lesions of the hip in the paediatric age: a review of the Rizzoli experience.

作者信息

Ruggieri P, Angelini A, Montalti M, Pala E, Calabrò T, Ussia G, Abati C N, Mercuri M

机构信息

Department of Orthopedics, University of Bologna, Istituto Ortopedico Rizzoli, Via Pupilli, 1, Bologna 40136, Italy.

出版信息

Hip Int. 2009 Jan-Mar;19 Suppl 6:S35-45. doi: 10.1177/112070000901906s07.

DOI:10.1177/112070000901906s07
PMID:19306246
Abstract

Bone tumours and tumour-like lesions of the hip in children are rare. Signs and symptoms of these tumours are generally nonspecific. Delay of diagnosis is not uncommon. A high index of suspicion in young patients presenting with persistent pain and without history of trauma, that is unresolved with conservative therapy should prompt further investigation, including radiographs or computed tomography scan of the pelvis. In the experience of the Istituto Rizzoli, in patients less than 14 years (mean 9 years, ranged from 6 months to 14 years), 752 tumours and tumours-like lesions occurred in the pelvis or proximal femur, involving the hip. Tumour-like lesions accounted for 322 cases (simple bone cyst in 255, eosinophilic granuloma in 43, aneurismal bone cyst in 34), benign tumours for 340 cases (osteoid osteoma in 229, fibrous dysplasia in 63, exostosis in 48) and malignant tumours for 80 cases (Ewing's sarcoma in 53 and osteosarcoma in 27). The epidemiology, pathology, clinical presentation, and radiograph findings are discussed for each of these tumours.Treatment of these tumours differs from observation or minimally invasive treatment for most pseudotumoural lesions, intralesional excision or termoablation for benign bone tumours and wide resection for malignant bone tumours. In this latter group, chemotherapy is required and often administered pre- and postoperatively.

摘要

儿童髋部的骨肿瘤和肿瘤样病变较为罕见。这些肿瘤的体征和症状通常不具有特异性。诊断延迟并不少见。对于出现持续性疼痛且无创伤史、经保守治疗仍未缓解的年轻患者,高度怀疑应促使进一步检查,包括骨盆的X线片或计算机断层扫描。根据里佐利研究所的经验,在14岁以下(平均9岁,范围从6个月至14岁)的患者中,752例肿瘤和肿瘤样病变发生在骨盆或股骨近端,累及髋部。肿瘤样病变占322例(单纯骨囊肿255例、嗜酸性肉芽肿43例、动脉瘤样骨囊肿34例),良性肿瘤340例(骨样骨瘤229例、骨纤维发育不良63例、骨外生骨疣48例),恶性肿瘤80例(尤因肉瘤53例、骨肉瘤27例)。本文将对每种肿瘤的流行病学、病理学、临床表现和X线表现进行讨论。这些肿瘤的治疗方法各不相同,大多数假肿瘤性病变采用观察或微创治疗,良性骨肿瘤采用病灶内切除或热消融,恶性骨肿瘤采用广泛切除。对于后一组患者,需要进行化疗,且通常在术前和术后给药。

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