尽管促肾上腺皮质激素（ACTH）分泌出现显著的急性或慢性变化，但大鼠下丘脑促肾上腺皮质激素释放因子（CRF）的含量仍保持恒定。

Rat hypothalamic corticotropin-releasing factor (CRF) content remains constant despite marked acute or chronic changes in ACTH secretion.

作者信息

Yasuda N, Greer M A

出版信息

Neuroendocrinology. 1976;22(1):48-56. doi: 10.1159/000122611.

PMID:193065

Abstract

Hypothalamic corticotropin-releasing factor (CRF) activity was only slightly increased by 1 min ether stress and was unaltered by 2.5-10 min ether stress, 15-day adrenalectomy, 11-day hypophysectomy or 3-day dexamethasone treatment. There was a slight tendency for the hypothalamic CRF activity to be higher in the p.m. than in the a.m. Basal hypothalamic deafferentation did not significantly affect hypothalamic CRF content in the a.m. or p.m. compared to intact controls. We conclude that hypothalamic CRF content maintains relative constancy under conditions of marked acute or chronic stimulation or suppression of ACTH secretion.

摘要

下丘脑促肾上腺皮质激素释放因子（CRF）活性在1分钟乙醚应激时仅略有增加，而在2.5 - 10分钟乙醚应激、15天肾上腺切除术、11天垂体切除术或3天地塞米松治疗后未发生改变。下丘脑CRF活性有轻微的趋势是下午高于上午。与完整对照组相比，基础下丘脑去传入神经支配对上午或下午下丘脑CRF含量无显著影响。我们得出结论，在促肾上腺皮质激素（ACTH）分泌受到明显急性或慢性刺激或抑制的情况下，下丘脑CRF含量保持相对恒定。