用于表征心肌生物学特性的新型分子成像靶点。
New molecular imaging targets to characterize myocardial biology.
作者信息
Morrison Alan R, Sinusas Albert J
机构信息
Yale University School of Medicine, Section of Cardiovascular Medicine, New Haven, CT 06520-8017, USA.
出版信息
Cardiol Clin. 2009 May;27(2):329-44, Table of Contents. doi: 10.1016/j.ccl.2008.12.008.
Molecular imaging represents a targeted approach to noninvasively assess biologic (both physiologic and pathologic) processes in vivo. Ideally the goal of molecular imaging is not just to provide diagnostic and prognostic information based on identification of the molecular events associated with a pathologic process but rather to guide individually tailored pharmacologic, cell-based, or genetic therapeutic regimens. This article reviews the recent advances in myocardial molecular imaging in the context of the cardiovascular processes of angiogenesis, apoptosis, inflammation, and ventricular remodeling. The focus is on radiotracer-based single photon emission computed tomography and positron emission tomography molecular imaging approaches.
分子成像代表了一种在体内非侵入性评估生物（包括生理和病理）过程的靶向方法。理想情况下，分子成像的目标不仅仅是基于识别与病理过程相关的分子事件来提供诊断和预后信息，而是指导个体化定制的药物、细胞或基因治疗方案。本文在血管生成、细胞凋亡、炎症和心室重构等心血管过程的背景下，综述了心肌分子成像的最新进展。重点是基于放射性示踪剂的单光子发射计算机断层扫描和正电子发射断层扫描分子成像方法。
Zotero 插件