Calderón González R
Centro Neurológico para Niños y Adolescentes CENNA, Escuela de Medicina Ignacio A. Santos, Hospital San José, ITESM Monterrey, Nuevo León, México.
Bol Med Hosp Infant Mex. 1991 Jul;48(7):469-73.
The parents of 17 children with a history of convulsions, were shown how to administer liquid diazepam through the rectum using a 1 mL insulin syringe, in order to alleviate a convulsion at home or any where ever this may occur. Eight of the children had suffered from repetitive and/or prolonged non-temperature related convulsions, four had epileptic status and five had suffered from simple fever related convulsions, complicated in four and in a convulsive status in 1; the number of fever-related convulsions ranged between 1 and 6 per child and those non temperature related ranged from one daily to once a month. The observation of the children was done in an 88 month period (between 1 and nine months per child, averaging 5.2 months). In seven of the children, it was required of the parents to administer rectal diazepam a total of 90 times (fluctuating between 2 and 25 doses per child), with no complications, a dose of 0.5 mg/kg was administered in those patients whose convulsions lasted over 5 minutes or more. In 75 occasions, the convulsion stopped within a period of 2 to 5 minutes, in 12 other times there was a need for repeated dosages and in 2 occasions, a third doses was needed. Only in one occasion was hospital management needed. Therefore, we conclude that the administration of rectal diazepam by parents--at home--is a useful and secure method to prevent prolonged convulsions and the epileptic status; it gives parents security and tranquility using an instrument which can be used in any circumstance therefore reducing anguish and the cost of hospital care.(ABSTRACT TRUNCATED AT 250 WORDS)
向17名有惊厥病史儿童的家长展示了如何使用1毫升胰岛素注射器经直肠给予地西泮溶液,以便在家中或惊厥发生的任何地点缓解惊厥。其中8名儿童患有反复和/或持续性非体温相关惊厥,4名患有癫痫持续状态,5名患有单纯发热相关惊厥,4名出现并发症,1名处于惊厥状态;每名儿童发热相关惊厥次数在1至6次之间,非体温相关惊厥次数从每日1次到每月1次不等。对这些儿童的观察持续了88个月(每名儿童1至9个月,平均5.2个月)。7名儿童的家长共需经直肠给予地西泮90次(每名儿童2至25剂不等),无并发症发生,惊厥持续超过5分钟或更长时间的患者给予0.5毫克/千克的剂量。75次惊厥在2至5分钟内停止,另外12次需要重复给药,2次需要第三次给药。仅1次需要住院治疗。因此,我们得出结论,家长在家中经直肠给予地西泮是预防惊厥持续状态和癫痫持续状态的一种有用且安全的方法;使用一种可在任何情况下使用的器械让家长感到安心,从而减少痛苦和住院护理费用。(摘要截选至250字)