Nanda Sudip, Longo Santo, Bhatt Surya Prakash, Pamula John, Sharma Shree Gopal, Dale Thompson H
Department of Internal Medicine, St. Luke's Hospital, Bethlehem, PA, USA.
Ann Clin Biochem. 2009 May;46(Pt 3):257-60. doi: 10.1258/acb.2009.008237. Epub 2009 Mar 23.
We have documented a unique instance of diabetic ketoacidosis (DKA)-induced stress-related cardiomyopathy (CMP) in a 46-yr-old Caucasian female with type I diabetes mellitus. In times of stress, tissues with high capacity for aerobic metabolism, like myocardium, can preferentially change their metabolic substrate to ketones. The myocyte has a decreased ability to metabolize glucose and free fatty acids in stress CMP. To the best of our knowledge this is the first report of stress CMP complicating DKA. A possible mechanism for the same is hypothesized.
我们记录了一例独特的糖尿病酮症酸中毒（DKA）诱发的应激性心肌病（CMP）病例，患者为一名46岁的I型糖尿病白种女性。在应激状态下，具有高有氧代谢能力的组织，如心肌，可优先将其代谢底物转变为酮体。在应激性心肌病中，心肌细胞代谢葡萄糖和游离脂肪酸的能力下降。据我们所知，这是首例DKA并发应激性心肌病的报告。本文还对其可能的机制进行了推测。
