Godden S M, Haines D M, Hagman D
Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN 55108, USA.
J Dairy Sci. 2009 Apr;92(4):1750-7. doi: 10.3168/jds.2008-1846.
The objective of this study was to describe the effects of feeding 1 or 2 doses of a commercially available colostrum-derived colostrum replacer (CR) on passive transfer of immunoglobulins (Ig) in newborn dairy calves, including IgG, IgG1, IgG2, IgA, and IgM. Newborn calves were removed from the dam before suckling and randomly assigned to 1 of 3 treatment groups: group 1 were fed 1 package (100 g of IgG) of CR product, group 2 was fed 2 packages (200 g of IgG) of the same CR product, and group 3 was fed 3.8 L of maternal colostrum. All colostrum treatments were fed using an esophageal tube feeder within 2 h of birth. Blood samples collected before colostrum feeding and at 24 h of age were tested for serum total protein and Ig concentrations. Mean 24-h serum total protein (TP) and IgG concentrations were significantly lower for calves in group 1 (n = 24; TP = 4.9 g/dL, IgG = 9.6 mg/mL) compared with calves in groups 2 or 3. There was no difference in 24-h serum TP or IgG concentrations between calves in group 2 (n = 23; TP = 5.5 g/dL, IgG = 19.0 mg/mL) and calves in group 3 (n = 22; TP = 5.7 g/dL, IgG = 20.7 mg/mL). Fifty-four, 100, and 91% of calves in groups 1, 2 and 3 achieved acceptable passive transfer (24-h serum IgG > or =10 mg/mL), respectively. Statistically significant but numerically small differences existed between calves in groups 2 and 3 for some 24-h serum Ig classes and subclasses (mean serum concentrations of IgG2, IgA, IgM) and for the relative percentages of Ig classes and subclasses (IgA, IgM, and IgG as a percentage of total Ig; IgG1 and IgG2 as a percentage of total IgG).
本研究的目的是描述给新生奶牛犊饲喂1剂或2剂市售初乳源初乳代用品（CR）对免疫球蛋白（Ig）被动转移的影响，包括IgG、IgG1、IgG2、IgA和IgM。新生犊牛在吮乳前与母牛分开，并随机分配到3个处理组中的1组：第1组饲喂1包（100 g IgG）CR产品，第2组饲喂2包（200 g IgG）相同的CR产品，第3组饲喂3.8 L母源初乳。所有初乳处理均在出生后2小时内通过食管饲管进行饲喂。采集初乳饲喂前和24小时龄的血样，检测血清总蛋白和Ig浓度。与第2组或第3组的犊牛相比，第1组（n = 24；总蛋白=4.9 g/dL，IgG = 9.6 mg/mL）犊牛的24小时血清总蛋白（TP）和IgG浓度显著较低。第2组（n = 23；总蛋白=5.5 g/dL，IgG = 19.0 mg/mL）犊牛和第3组（n = 22；总蛋白=5.7 g/dL，IgG = 20.7 mg/mL）犊牛的24小时血清总蛋白或IgG浓度没有差异。第1组、第2组和第3组分别有54%、100%和91%的犊牛实现了可接受的被动转移（24小时血清IgG≥10 mg/mL）。在24小时血清Ig类别和亚类（IgG2、IgA、IgM的平均血清浓度）以及Ig类别和亚类的相对百分比（IgA、IgM和IgG占总Ig的百分比；IgG1和IgG2占总IgG的百分比）方面，第2组和第3组的犊牛之间存在统计学上显著但数值较小的差异。
