通用转录因子TFIID结构与功能研究的最新进展
Recent advances in understanding the structure and function of general transcription factor TFIID.
作者信息
Cler Emilie, Papai Gabor, Schultz Patrick, Davidson Irwin
机构信息
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 1 Rue Laurent Fries, 67404, Illkirch Cedex, France.
出版信息
Cell Mol Life Sci. 2009 Jul;66(13):2123-34. doi: 10.1007/s00018-009-0009-3. Epub 2009 Mar 24.
Abstract
The general transcription factor TFIID is a macromolecular complex comprising the TATA-binding protein (TBP) and a set of 13-14 TBP associated factors (TAFs). This review discusses biochemical, genetic and electron microscopic data acquired over the past years that provide a model for the composition, organisation and assembly of TFIID. We also revisit ideas on how TFIID is recruited to the promoters of active and possibly repressed genes. Recent observations show that recognition of acetylated and methylated histone residues by structural domains in several TAFs plays an important role. Finally, we highlight several genetic studies suggesting that TFIID is required for initiation of transcription, but not for maintaining transcription once a promoter is in an active state.
摘要
通用转录因子TFIID是一种大分子复合物，由TATA结合蛋白（TBP）和一组13 - 14个TBP相关因子（TAFs）组成。本综述讨论了过去几年获得的生化、遗传和电子显微镜数据，这些数据为TFIID的组成、组织和组装提供了一个模型。我们还重新审视了关于TFIID如何被招募到活跃基因和可能被抑制基因的启动子上的观点。最近的观察表明，几个TAF中的结构域对乙酰化和甲基化组蛋白残基的识别起着重要作用。最后，我们强调了几项遗传学研究，这些研究表明TFIID是转录起始所必需的，但一旦启动子处于活跃状态，它对于维持转录不是必需的。
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Structure. 2009 Mar 11;17(3):363-73. doi: 10.1016/j.str.2009.01.006.
2
Crosstalk among Histone Modifications.组蛋白修饰之间的串扰。
Cell. 2008 Nov 14;135(4):604-7. doi: 10.1016/j.cell.2008.10.036.
3
The TBP-PP2A mitotic complex bookmarks genes by preventing condensin action.TBP-PP2A有丝分裂复合体通过阻止凝聚素的作用来标记基因。
Nat Cell Biol. 2008 Nov;10(11):1318-23. doi: 10.1038/ncb1790. Epub 2008 Oct 19.
4
Global transcriptional repression in C. elegans germline precursors by regulated sequestration of TAF-4.通过对TAF-4的调控性隔离实现秀丽隐杆线虫生殖系前体细胞中的全局转录抑制。
Cell. 2008 Oct 3;135(1):149-60. doi: 10.1016/j.cell.2008.07.040.
5
Dominant and redundant functions of TFIID involved in the regulation of hepatic genes.TFIID在肝脏基因调控中的主导和冗余功能。
Mol Cell. 2008 Aug 22;31(4):531-543. doi: 10.1016/j.molcel.2008.07.013.
6
Cooperative action of NC2 and Mot1p to regulate TATA-binding protein function across the genome.NC2和Mot1p在全基因组范围内协同调节TATA结合蛋白功能的作用。
Genes Dev. 2008 Sep 1;22(17):2359-69. doi: 10.1101/gad.1682308. Epub 2008 Aug 14.
7
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Structure. 2008 Aug 6;16(8):1245-56. doi: 10.1016/j.str.2008.04.015.
8
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Mol Cells. 2008 Sep 30;26(3):217-27. Epub 2008 Jul 30.
9
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Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8884-9. doi: 10.1073/pnas.0712293105. Epub 2008 Jun 25.
10
Diverse functions of WD40 repeat proteins in histone recognition.WD40重复蛋白在组蛋白识别中的多种功能。
Genes Dev. 2008 May 15;22(10):1265-8. doi: 10.1101/gad.1676208.
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