通用转录因子TFIID结构与功能研究的最新进展
Recent advances in understanding the structure and function of general transcription factor TFIID.
作者信息
Cler Emilie, Papai Gabor, Schultz Patrick, Davidson Irwin
机构信息
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 1 Rue Laurent Fries, 67404, Illkirch Cedex, France.
出版信息
Cell Mol Life Sci. 2009 Jul;66(13):2123-34. doi: 10.1007/s00018-009-0009-3. Epub 2009 Mar 24.
Abstract
The general transcription factor TFIID is a macromolecular complex comprising the TATA-binding protein (TBP) and a set of 13-14 TBP associated factors (TAFs). This review discusses biochemical, genetic and electron microscopic data acquired over the past years that provide a model for the composition, organisation and assembly of TFIID. We also revisit ideas on how TFIID is recruited to the promoters of active and possibly repressed genes. Recent observations show that recognition of acetylated and methylated histone residues by structural domains in several TAFs plays an important role. Finally, we highlight several genetic studies suggesting that TFIID is required for initiation of transcription, but not for maintaining transcription once a promoter is in an active state.
摘要
通用转录因子TFIID是一种大分子复合物，由TATA结合蛋白（TBP）和一组13 - 14个TBP相关因子（TAFs）组成。本综述讨论了过去几年获得的生化、遗传和电子显微镜数据，这些数据为TFIID的组成、组织和组装提供了一个模型。我们还重新审视了关于TFIID如何被招募到活跃基因和可能被抑制基因的启动子上的观点。最近的观察表明，几个TAF中的结构域对乙酰化和甲基化组蛋白残基的识别起着重要作用。最后，我们强调了几项遗传学研究，这些研究表明TFIID是转录起始所必需的，但一旦启动子处于活跃状态，它对于维持转录不是必需的。
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