Pietsch M, Wenisch C, Hofmann S
Abteilung für Orthopädie und orthopädische Chirurgie, Allgemeines und orthopädisches LKH, Stolzalpe, Osterreich.
Orthopade. 2009 Apr;38(4):348-54. doi: 10.1007/s00132-009-1411-0.
The 2-5-year results for the treatment of deep infection of total knee arthroplasty (TKA) after two-stage reimplantation are presented. An articulating temporary antibiotic spacer prosthesis (TASP) and a standardized antibiotic regimen were used.
In a prospective study, 33 consecutive patients were treated with TASP. This articulating spacer was made on the table by cleaning and autoclaving removed parts of the TKA. Intravenous double antibiotic therapy in combination with rifampin was given for 10 days, followed by oral therapy for 4 weeks.
At a mean follow-up period of 47 months (31-67), three patients had reinfection (success rate 91%). The average Hospital for Special Surgery knee score increased from 67 points (44-84) to 85 points (53-97) after reimplantation. Based on these results, 24 knees (73%) were rated excellent, five (15%) were rated good, three (9%) were rated fair, and one patient (3%) had a poor result. Complications included one case of temporary peroneal palsy, one dislocation of the spacer due to an insufficient extensor mechanism, and one fracture of the tibia due to substantial primary metaphyseal bone loss.
Using TASP, the disadvantages of joint fixation between the two stages could be reduced. There was no difference in the reinfection rate compared with procedures using fixed spacer blocks. TASP facilitates reimplantation and yields good functional results.
本文介绍了两阶段再植入后全膝关节置换术(TKA)深部感染治疗的2至5年结果。使用了一种可活动的临时抗生素间隔假体(TASP)和标准化的抗生素治疗方案。
在一项前瞻性研究中,连续33例患者接受了TASP治疗。这种可活动的间隔假体是在手术台上通过对取出的TKA部件进行清洗和高压灭菌制成的。静脉给予联合利福平的双重抗生素治疗10天,随后口服治疗4周。
平均随访期为47个月(31至67个月),3例患者再次感染(成功率91%)。再植入后,特殊外科医院膝关节平均评分从67分(44至84分)提高到85分(53至97分)。基于这些结果,24个膝关节(73%)评定为优,5个(15%)评定为良,3个(9%)评定为中,1例患者(3%)结果差。并发症包括1例暂时性腓总神经麻痹、1例因伸肌机制不足导致的间隔假体脱位以及1例因干骺端大量骨质流失导致的胫骨骨折。
使用TASP可减少两阶段之间关节固定的缺点。与使用固定间隔块的手术相比,再次感染率没有差异。TASP便于再植入并产生良好的功能结果。