[原发性皮肤苔藓样和斑状淀粉样变的组织病理学表现]
[Histopathological findings of primary cutaneous lichenoid and macular amyloidosis].
作者信息
Yang Min, Li Lin-Feng, Chang Jian-Min
机构信息
Department of Dermatology, Peking University Third Hospital, Beijing 100083, China.
出版信息
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2009 Feb;31(1):31-3.
OBJECTIVE
To investigate the histopathological findings of primary cutaneous lichenoid amyloidosis (LA) and macular amyloidosis (MA).
METHODS
The pathological features of 82 patients with primary cutaneous amyloidosis (PCA) admitted from 2003 to 2008 were summarized.
RESULTS
There were 52 cases (63%) of LA and 30 cases (37%) of MA, among which 49 cases (60%) presented with pyknotic nucleus of the basal keratinocytes above the amyloid in the upper dermis and 18 cases (22%) presented with pagetoid dyskeratosis (PD) cells among their prickle cells. More amyloid in LA and more severe incontinent of pigment in MA. The deposition level of amyloid protein was significantly higher in patients with LA and the incontinent of pigment was significantly higher in patients with MA (P < 0.01).
CONCLUSION
The amyloid protein may be derived from the apoptotic keratinocytes.
目的
探讨原发性皮肤苔藓样淀粉样变（LA）和斑状淀粉样变（MA）的组织病理学表现。
方法
总结2003年至2008年收治的82例原发性皮肤淀粉样变（PCA）患者的病理特征。
结果
LA患者52例（63%），MA患者30例（37%），其中49例（60%）真皮上层淀粉样变上方基底角质形成细胞核固缩，18例（22%）棘细胞中有佩吉特样角化不良（PD）细胞。LA中淀粉样物更多，MA中色素失禁更严重。LA患者淀粉样蛋白沉积水平显著更高，MA患者色素失禁显著更高（P < 0.01）。
结论
淀粉样蛋白可能来源于凋亡的角质形成细胞。
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