Leonforte J F
Service de Dermatologie, Policlinique Ferroviaire de Mendoza, Argentine.
Ann Dermatol Venereol. 1987;114(6-7):801-6.
This study is based on clinical findings in 160 patients with skin-limited amyloidosis: 151 macular, 8 biphasic and 1 lichen amyloidosis. 82.5 p. 100 of the patients were women and 17.5 p. 100 were men. 95 p. 100 of the patches were located in the back and 64 p. 100 in the suprascapular region. No less than 88 p. 100 of the patients had pruritus on the patches or on other sites. 75 p. 100 had allergic diseases or a history of allergy, and 45 p. 100 had non-allergic pruriginous diseases. Signs of scratching were noted in most of the patients. The principal causes of pruritus were dermographism, photodermatitis and dermatitis. Macular amyloidosis is now considered as secondary to scratching motivated by pruriginous diseases and not as a primary condition as hitherto described. The term "scratch amyloidosis" is proposed for macular and lichenoid amyloidosis, and the existence of a "preamyloidotic" histological stage is described.
本研究基于160例皮肤局限性淀粉样变患者的临床发现：151例为斑状，8例为双相性，1例为苔藓样淀粉样变。患者中82.5%为女性，17.5%为男性。95%的斑块位于背部，64%位于肩胛上区域。不少于88%的患者在斑块处或其他部位有瘙痒。75%有过敏性疾病或过敏史，45%有非过敏性瘙痒性疾病。大多数患者有搔抓迹象。瘙痒的主要原因是皮肤划痕症、光性皮炎和皮炎。斑状淀粉样变现在被认为是由瘙痒性疾病引起搔抓的继发性表现，而非如迄今所描述的原发性疾病。对于斑状和苔藓样淀粉样变，提出了“搔抓性淀粉样变”这一术语，并描述了“淀粉样变前期”组织学阶段的存在。
