钯催化苯甲酸通过串联脱羧/C-H活化进行分子内直接芳基化反应。
Palladium-catalyzed intramolecular direct arylation of benzoic acids by tandem decarboxylation/C-H activation.
作者信息
Wang Congyang, Piel Isabel, Glorius Frank
机构信息
Organisch-Chemisches Institut der Westfälischen Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany.
出版信息
J Am Chem Soc. 2009 Apr 1;131(12):4194-5. doi: 10.1021/ja8100598.
PMID:19317495
Abstract
A novel protocol for the palladium-catalyzed intramolecular direct arylation of benzoic acids is reported, which combines decarboxylation and C-H activation into one efficient process. With the optimized catalyst system of palladium trifluoroacetate, silver carbonate, and the proper solvent mixture (5% DMSO/dioxane), dibenzofuran derivatives are formed in excellent yield and selectivity.
摘要
报道了一种用于钯催化苯甲酸分子内直接芳基化的新方案，该方案将脱羧和C-H活化结合成一个高效过程。使用三氟乙酸钯、碳酸银和适当的溶剂混合物（5%二甲基亚砜/二氧六环）的优化催化剂体系，可高产率和高选择性地形成二苯并呋喃衍生物。
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