氧化铝促进的氧脱氟反应。

Vladimir Akhmetov, Mikhail Feofanov, Amsharov Konstantin

Friedrich-Alexander University Erlangen-Nuernberg, Department of Chemistry and Pharmacy, Organic Chemistry II Nikolaus-Fiebiger Str. 10 91058 Erlangen Germany

Institute of Chemistry, Organic Chemistry, Martin-Luther-University Halle-Wittenberg Kurt-Mothes-Strasse 2 D-06120 Halle Germany.

RSC Adv. 2020 Mar 17;10(18):10879-10882. doi: 10.1039/d0ra01369b. eCollection 2020 Mar 11.

A simple protocol for the clean preparation of heterocyclic compounds containing dibenzofuran's core oxodefluorination of fluoroarenes on activated γ-AlO is reported. Alumina can be considered as a reliable oxygen source enabling one-pot substitution of fluorine atoms and yielding benzoannulated furan derivatives. The corresponding C-F bond activation is selective towards less stable C-Br/C-I and occurs under metal- and solvent-free conditions.

报道了一种在活性γ-氧化铝上对含二苯并呋喃核心的氟芳烃进行清洁制备杂环化合物的简单方案——氧脱氟反应。氧化铝可被视为一种可靠的氧源，能够实现氟原子的一锅法取代，并生成苯并稠合呋喃衍生物。相应的C-F键活化对较不稳定的C-Br/C-I具有选择性，且在无金属和无溶剂条件下发生。