钯催化噻唑、苯并恶唑和取代苯甲酸与多氟苯的脱羧芳基化反应。

Pd-catalyzed decarboxylative arylation of thiazole, benzoxazole, and polyfluorobenzene with substituted benzoic acids.

机构信息

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.

出版信息

Org Lett. 2010 Apr 2;12(7):1564-7. doi: 10.1021/ol100296b.

DOI:10.1021/ol100296b

PMID:20201587

Abstract

A Pd-catalyzed decarboxylative coupling of thiazoles and benzoxazole with various substituted benzoic acids is developed. The reaction is compatible with both electron-rich and electron-poor benzoic acids. It can also be extended to the synthesis of polyfluoro-substituted biaryls using polyfluorobenzenes as the starting materials.

摘要

Pd 催化噻唑和苯并恶唑与各种取代苯甲酸的脱羧偶联反应得到发展。该反应与富电子和缺电子苯甲酸都兼容。它还可以扩展到使用多氟苯作为起始原料来合成多氟取代联芳烃。