Mitry Danny, Charteris David G, Yorston David, Fleck Brian W, Wright Alan, Campbell Harry, Singh Jaswinder
Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh, UK.
BMC Ophthalmol. 2009 Mar 24;9:2. doi: 10.1186/1471-2415-9-2.
Rhegmatogenous retinal detachment (RRD) is a potentially blinding condition and a common cause of ocular morbidity. Establishing an accurate estimate of disease incidence and distribution is an important first step in assessing the healthcare burden related to this condition and in subsequent planning and provision of treatment strategies. The aim of this study is to obtain a first estimate incidence of RRD in Scotland, to estimate the incidence of familial RRD and to describe the known associations of RRD within the study population.
METHODS/DESIGN: We have established a national prospective observational study seeking to identify and recruit all incident cases of RRD in the Scottish population over a 2 year period. After fully informed consent, all participants will have a blood sample taken and a full medical history and clinical examination performed including visual acuity, refraction, slit-lamp examination, intra-ocular pressure measurement and detailed fundal examination. We describe the study design and protocol.
This study will provide the first estimate of the annual incidence of RRD in Scotland. The findings of this study will be important in estimating the burden of disease and in the planning of future health care policy related to this condition. This study will also establish a genetic resource for a genome wide association study to investigate if certain genetic variants predispose to RRD.
孔源性视网膜脱离（RRD）是一种可能致盲的疾病，也是眼部发病的常见原因。准确估计疾病的发病率和分布情况是评估与该疾病相关的医疗负担以及后续制定和提供治疗策略的重要第一步。本研究的目的是首次估计苏格兰RRD的发病率，估计家族性RRD的发病率，并描述研究人群中已知的RRD相关因素。
方法/设计：我们开展了一项全国性前瞻性观察研究，旨在识别和招募苏格兰人群中在两年时间内所有RRD新发病例。在获得充分知情同意后，所有参与者将采集血样，并进行全面的病史采集和临床检查，包括视力、验光、裂隙灯检查、眼压测量和详细的眼底检查。我们描述了研究设计和方案。
本研究将首次估计苏格兰RRD的年发病率。本研究结果对于估计疾病负担以及制定与该疾病相关的未来医疗政策具有重要意义。本研究还将建立一个用于全基因组关联研究的遗传资源，以调查某些基因变异是否易患RRD。
