Zava D T, Chamness G C, Horwitz K B, McGuire W L
Science. 1977 May 6;196(4290):663-4. doi: 10.1126/science.193182.
The human breast cancer cell line MCF-7 does not require estrogen for growth, but paradoxically its growth is inhibited by antiestrogens. Our results show that, unlike normal target cells, MCF-7 cells carry most of their estrogen receptors in their nuclei even when these receptors are not charged with estrogens. The receptors for androgen and for progesterone, on the other hand, are localized in the cytoplasm as usual. Therefore, it is possible that the growth of these abnormal cells is stimulated by estrogen receptor in spite of the absence of the hormone and that the binding of antiestrogen molecules antagonize this stimulation.
人乳腺癌细胞系MCF - 7的生长不需要雌激素，但矛盾的是，其生长会被抗雌激素抑制。我们的结果表明，与正常靶细胞不同，即使MCF - 7细胞的雌激素受体未结合雌激素，其大部分雌激素受体仍位于细胞核中。另一方面，雄激素和孕激素受体则像往常一样定位于细胞质中。因此，尽管缺乏激素，但这些异常细胞的生长仍可能受到雌激素受体的刺激，而抗雌激素分子的结合会拮抗这种刺激。
