Guo Yongjian, Ribeiro Jose M C, Anderson Jennifer M, Bour Stephan
Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology and Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
Bioinformatics. 2009 May 1;25(9):1195-6. doi: 10.1093/bioinformatics/btp129. Epub 2009 Mar 24.
Understanding gene regulation and expression is the key to the advancement of biology. EST sequence assembly and analysis provide unique benefits in this regard. We have developed a standalone application, dCAS (Desktop cDNA Annotation System), which performs automated EST cleaning, clustering, assembly and annotation on a desktop computer. Compared with other available tools, dCAS provides a more convenient and user-friendly solution to biologists for extracting biological meaning from sequence data.
The dCAS package is distributed freely. A cross-platform installer and associated sequence databases can be downloaded at: http://exon.niaid.nih.gov/applications.html.
理解基因调控和表达是生物学进步的关键。EST序列组装和分析在这方面具有独特的优势。我们开发了一个独立应用程序dCAS(桌面cDNA注释系统),它可以在台式计算机上对EST进行自动清理、聚类、组装和注释。与其他现有工具相比,dCAS为生物学家从序列数据中提取生物学意义提供了更便捷且用户友好的解决方案。
dCAS软件包可免费分发。可从以下网址下载跨平台安装程序和相关序列数据库:http://exon.niaid.nih.gov/applications.html 。