Hatachmi Sarel
Urology, Rambam Health Care Campus, Israel.
Harefuah. 2009 Jan;148(1):66-9, 86.
Superficial bladder cancer is a chronically relapsing, non-curable disease. Its biological tendency to recur and progress mandates close follow-up for the early detection of recurrent tumors. The methods used for bladder cancer detection are either invasive or have low sensitivity. In recent years there is a constant effort to find a better non-invasive moLecuLar marker for bladder cancer. This manuscript will review published genetic changes associated with the development of bladder cancer and the advantages of molecuLar diagnosis and will also present some of the markers that have been tested.
浅表性膀胱癌是一种慢性复发性、不可治愈的疾病。其复发和进展的生物学倾向要求进行密切随访，以便早期发现复发性肿瘤。用于膀胱癌检测的方法要么具有侵入性，要么灵敏度较低。近年来，人们一直在不断努力寻找一种更好的非侵入性膀胱癌分子标志物。本文将综述已发表的与膀胱癌发生相关的基因变化以及分子诊断的优势，并介绍一些已进行测试的标志物。
