Addolorato Giovanni, Leggio Lorenzo, Hillemacher Thomas, Kraus Thomas, Jerlhag Elisabet, Bleich Stefan
Institute of Internal Medicine, Catholic University of Rome, Largo A. Gemelli 8, Rome, Italy.
Drug Alcohol Rev. 2009 Mar;28(2):160-5. doi: 10.1111/j.1465-3362.2008.00023.x.
There is growing evidence for a role of appetite-related peptides and volume-regulating hormones in alcoholism. In particular, recent evidence has suggested that hormones, such as ghrelin, insulin and leptin and volume-regulating hormones, could play a role in alcohol-seeking behaviour. The goal of this review is to discuss the results of recent preclinical and clinical investigations on this topic. The findings indicate that neuroendocrinological mechanisms are potentially involved in the neurobiology of alcohol craving. Accordingly, research on this topic could lead to possible development of new therapeutic approaches in the treatment of patients with alcohol problems.
越来越多的证据表明，与食欲相关的肽和容量调节激素在酒精中毒中发挥作用。特别是，最近的证据表明，诸如胃饥饿素、胰岛素和瘦素等激素以及容量调节激素可能在觅酒行为中起作用。本综述的目的是讨论近期关于该主题的临床前和临床研究结果。研究结果表明，神经内分泌机制可能参与了酒精渴望的神经生物学过程。因此，对该主题的研究可能会导致在治疗酒精问题患者方面开发出新的治疗方法。
