奥卡西平诱发的史蒂文斯-约翰逊综合征：一例报告
Oxcarbazepine-induced Stevens-Johnson syndrome: a case report.
作者信息
Lin Lung-Chang, Lai Ping-Chin, Yang Sheau-Fang, Yang Rei-Cheng
机构信息
Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
出版信息
Kaohsiung J Med Sci. 2009 Feb;25(2):82-6. doi: 10.1016/S1607-551X(09)70045-2.
Abstract
Although carbamazepine (CBZ) is the most common cause of Stevens-Johnson syndrome (SJS), a new anticonvulsant, oxcarbazepine, which is structurally related to carbamazepine, has been shown to induce SJS, although extremely rarely. Recently, a strong association was found between human leukocyte antigen (HLA) B1502 and CBZ-induced SJS/TEN in a Han Chinese population. Here, we report a case with SJS, which was induced by oxcarbazepine. HLA genotyping in the patient showed HLA-B1518/B4001. HLA-B1518 is a HLA-B15 variant. The genetic significance of HLA-B*1518 in association with oxcarbazepine-induced SJS needs to be further studied.
摘要
尽管卡马西平（CBZ）是史蒂文斯-约翰逊综合征（SJS）最常见的病因，但一种新的抗惊厥药奥卡西平，其结构与卡马西平相关，已被证明可诱发SJS，尽管极为罕见。最近，在汉族人群中发现人类白细胞抗原（HLA）B1502与CBZ诱发的SJS/TEN之间存在强关联。在此，我们报告一例由奥卡西平诱发SJS的病例。患者的HLA基因分型显示为HLA-B1518/B4001。HLA-B1518是HLA-B15的一个变体。HLA-B*1518与奥卡西平诱发SJS相关的遗传学意义有待进一步研究。
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