严重迟发性药物反应：遗传学和病毒感染的作用
Severe Delayed Drug Reactions: Role of Genetics and Viral Infections.
作者信息
Pavlos Rebecca, White Katie D, Wanjalla Celestine, Mallal Simon A, Phillips Elizabeth J
机构信息
Institute for Immunology and Infectious Diseases, Murdoch University, 6150 Murdoch, Western Australia, Australia.
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
出版信息
Immunol Allergy Clin North Am. 2017 Nov;37(4):785-815. doi: 10.1016/j.iac.2017.07.007.
Abstract
Adverse drug reactions (ADRs) are a significant source of patient morbidity and mortality and represent a major burden to health care systems and drug development. Up to 50% of such reactions are preventable. Although many ADRs can be predicted based on the on-target pharmacologic activity, ADRs arising from drug interactions with off-target receptors are recognized. Off-target ADRs include the immune-mediated ADRs (IM-ADRs) and pharmacologic drug effects. In this review, we discuss what is known about the immunogenetics and pathogenesis of IM-ADRs and the hypothesized role of heterologous immunity in the development of IM-ADRs.
摘要
药物不良反应（ADR）是患者发病和死亡的重要原因，也是医疗保健系统和药物研发的重大负担。高达50%的此类反应是可预防的。尽管许多ADR可根据靶向药理活性进行预测，但由药物与脱靶受体相互作用引起的ADR也已得到认识。脱靶ADR包括免疫介导的ADR（IM-ADR）和药物的药理作用。在本综述中，我们讨论了关于IM-ADR的免疫遗传学和发病机制的已知情况，以及异源免疫在IM-ADR发生发展中所假定的作用。
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