Maher K A
Gastroenterol Nurs. 1991 Oct;14(2):98-100. doi: 10.1097/00001610-199110000-00008.
Sincalide is a rapid-acting, synthetic analog of cholecystokinin for intravenous use in postevacuation cholecystography. Serious reactions to sincalide have not been reported. The intravenous administration of sincalide causes a prompt contraction of the gallbladder as compared to the stimulus of a fatty meal which causes progressive contraction that becomes maximal in about 40 minutes. The use of Kinevac to accelerate the transit time through the small bowel decreases the time and extent of radiation associated with fluoroscopy and length of the x-ray examination of the intestinal tract. Duodenal aspiration obtained after the administration of Kinevac provides a sample of concentrated bile for analysis of cholesterol, bile salts, phospholipids and crystals. When used in conjunction with secretin to stimulate pancreatic secretion, an aspirate is readily obtained for analysis of enzyme activity, composition and cytology. As the development of endoscopic manometry affords a modality to measure and record sphincter of Oddi pressures, the paradoxical responses noted to the intravenous administration of CCK during manometric evaluation supports the diagnostic value of Kinevac used as a provocative agent in the evaluation of biliary dyskinesia.
辛卡利特是一种作用迅速的合成缩胆囊素类似物，用于排空后胆囊造影的静脉注射。尚未有关于辛卡利特严重不良反应的报道。与脂肪餐刺激相比，静脉注射辛卡利特会使胆囊迅速收缩，脂肪餐刺激会导致胆囊逐渐收缩，约40分钟时收缩达到最大程度。使用凯内瓦（Kinevac）加速通过小肠的转运时间，可减少与荧光透视相关的辐射时间和范围以及肠道X线检查的时长。注射凯内瓦后获得的十二指肠抽吸物可提供浓缩胆汁样本，用于分析胆固醇、胆盐、磷脂和晶体。当与促胰液素联合使用以刺激胰腺分泌时，很容易获得抽吸物用于分析酶活性、成分和细胞学。随着内镜测压技术的发展，提供了一种测量和记录Oddi括约肌压力的方法，在测压评估期间静脉注射缩胆囊素时观察到的矛盾反应支持了凯内瓦作为激发剂在评估胆道运动障碍中的诊断价值。
