Sostre S, Canto M I, Kalloo A N
Division of Nuclear Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
Eur J Nucl Med. 1992;19(11):964-5. doi: 10.1007/BF00175863.
Patients on total parenteral nutrition or after prolonged fasting may require treatment with cholecystokinin (CCK) prior to hepatobiliary imaging. Some may also require evaluation of gallbladder (GB) contractility, and the need for a second dose of CCK may arise. It is not clear whether gallbladder function can be adequately evaluated with CCK when a previous CCK dose had already been administered. We studied ten normal subjects to evaluate GB response to a second CCK injection. The subjects received 20 micrograms/kg sincalide in a 3-min infusion prior to administration of technetium-99m disofenin. They then received an identical sincalide dose at 60 min postinjection, and imaging was continued for another 30 min to quantify GB contraction. Gallbladder ejection fraction (GBEF) values ranged from 42-98% (mean: 71.5 +/- 19%). Pretreatment with CCK does not preclude GB contraction evaluation with a second dose of CCK. Expected GBEF values are similar to those obtained with single CCK injections.
接受全胃肠外营养或长期禁食后的患者在进行肝胆成像之前可能需要用胆囊收缩素（CCK）进行治疗。一些患者可能还需要评估胆囊（GB）的收缩功能，可能需要注射第二剂CCK。当之前已经注射过CCK时，尚不清楚CCK是否能充分评估胆囊功能。我们研究了10名正常受试者，以评估GB对第二次CCK注射的反应。受试者在注射99m锝二巯基丁二酸之前，在3分钟内输注20微克/千克的辛卡利特。然后在注射后60分钟给予相同剂量的辛卡利特，并继续成像30分钟以量化GB收缩。胆囊射血分数（GBEF）值范围为42%-98%（平均：71.5 +/- 19%）。用CCK进行预处理并不妨碍用第二剂CCK评估GB收缩。预期的GBEF值与单次注射CCK时获得的值相似。
