Bediou Benoit, Ryff Ilham, Mercier Bernadette, Milliery Maud, Hénaff Marie-Anne, D'Amato Thierry, Bonnefoy Marc, Vighetto Alain, Krolak-Salmon Pierre
Université de Lyon, Service de Neurologie, Centre Hospitalier Lyon Sud, Lyon, F-69003, France.
J Geriatr Psychiatry Neurol. 2009 Jun;22(2):130-40. doi: 10.1177/0891988709332939. Epub 2009 Mar 25.
Abnormal decoding of social information has been associated with the conversion from prodromal Alzheimer's disease (AD) to dementia. Since the distributed neural networks involved in face processing are differentially affected in prodromal and dementia states of AD and in Fronto-Temporal Dementia (FTD), we hypothesized a differential impairment in face processing in these populations. Facial expression, gender and gaze direction decoding abilities were examined in patients with probable amnesic Mild Cognitive Impairment (aMCI, N=10) fulfilling criteria for prodromal AD, in patients with mild and moderate AD (N=10) as well as in FTD patients (N=10) and in a group of age- and sex-matched healthy comparison subjects (N=10). Gender recognition was preserved in all groups. Compared to controls, patients with mild or moderate AD were impaired in expression recognition and FTD patients were impaired in expression and gaze direction determination, whereas MCI patients were not impaired at all.
社会信息的异常解码与前驱期阿尔茨海默病(AD)向痴呆症的转化有关。由于参与面部处理的分布式神经网络在AD的前驱期和痴呆状态以及额颞叶痴呆(FTD)中受到不同程度的影响,我们推测这些人群在面部处理方面存在不同程度的损伤。对符合前驱期AD标准的可能遗忘型轻度认知障碍(aMCI,N = 10)患者、轻度和中度AD患者(N = 10)、FTD患者(N = 10)以及一组年龄和性别匹配的健康对照受试者(N = 10)的面部表情、性别和注视方向解码能力进行了检查。所有组别的性别识别能力均得以保留。与对照组相比,轻度或中度AD患者在表情识别方面受损,FTD患者在表情和注视方向判断方面受损,而MCI患者则完全没有受损。