de Boer Liset, van den Berg Esther, Poos Jackie M, Klop Willeke, Giannini Lucia A A, De Houwer Julie F H, Seelaar Harro, Jiskoot Lize C
Department of Neurology and Alzheimer Center Erasmus MC University Medical Center Rotterdam the Netherlands.
Dementia Research Center University College London London UK.
Alzheimers Dement (Amst). 2024 Sep 3;16(3):e12630. doi: 10.1002/dad2.12630. eCollection 2024 Jul-Sep.
We aimed to assess the knowledge of social norms in patients with behavioral variant frontotemporal dementia (bvFTD) with the Dutch version of the Social Norms Questionnaire (SNQ-NL).
The SNQ-NL was administered in 34 patients with bvFTD, 20 prodromal mutation carriers, 76 presymptomatic mutation carriers, and 56 controls. Group differences and correlations with other neuropsychological tests and gray matter volume were examined.
Patients with bvFTD had lower total SNQ-NL scores and more over-adherence errors than presymptomatic mutation carriers and controls (< 0.001). SNQ-NL performance correlated with tests for executive functioning and social cognition, and with gray matter volume in bilateral frontal and unilateral temporal regions.
The SNQ-NL can identify impairments in knowledge of social norms in bvFTD, highlighting its significance in clinical diagnosis and upcoming clinical trials. The SNQ-NL currently fails to differentiate presymptomatic mutation carriers from controls; to this end, larger sample sizes from larger cohorts and longitudinal follow-up are warranted.
The Dutch version of the Social Norms Questionnaire (SNQ-NL) is able to detect impairment in social cognition in symptomatic bvFTD patients.A trend towards a lower performance in prodromal mutation carriers was found.Performance on the SNQ-NL is related to other measures of social cognition, executive functioning, and language.Lower SNQ-NL performance is related to gray matter volume loss in bilateral frontal and temporal regions.The SNQ-NL provides insight into the underlying cause of deficits in social cognition in bvFTD.
我们旨在使用荷兰版社会规范问卷（SNQ-NL）评估行为变异型额颞叶痴呆（bvFTD）患者的社会规范知识。
对34例bvFTD患者、20例前驱期突变携带者、76例症状前突变携带者和56例对照者进行了SNQ-NL测试。检查了组间差异以及与其他神经心理学测试和灰质体积的相关性。
bvFTD患者的SNQ-NL总分低于症状前突变携带者和对照者，且过度遵守错误更多（<0.001）。SNQ-NL表现与执行功能和社会认知测试以及双侧额叶和单侧颞叶区域的灰质体积相关。
SNQ-NL可以识别bvFTD患者社会规范知识的损害，突出了其在临床诊断和即将进行的临床试验中的重要性。SNQ-NL目前无法区分症状前突变携带者和对照者；为此，需要来自更大队列的更大样本量和纵向随访。
荷兰版社会规范问卷（SNQ-NL）能够检测有症状bvFTD患者的社会认知损害。发现前驱期突变携带者有表现较低的趋势。SNQ-NL的表现与社会认知、执行功能和语言的其他测量指标相关。SNQ-NL表现较低与双侧额叶和颞叶区域的灰质体积减少有关。SNQ-NL为bvFTD社会认知缺陷的潜在原因提供了见解。
