Kubota K, Kurabayashi H, Kawada E, Okamoto K, Tamura J, Shirakura T
Department of Medicine, Kusatsu Branch Hospital, Gunma University School of Medicine, Japan.
Ann Hematol. 1991 Oct;63(4):232-3. doi: 10.1007/BF01703451.
A unique case of IgA kappa myeloma is presented. While the myeloma cells had secreted a large quantity of IgA kappa monoclonal protein, they were induced to stop secreting the monoclonal protein by cyclophosphamide and vincristine, in spite of a remarkable increase in tumor burden. The absence of intracytoplasmic IgA kappa was clearly evidenced by the immunofluorescence technique using anti-IgA and anti-kappa monoclonal antibodies.
本文报告了一例独特的IgA κ型骨髓瘤病例。尽管骨髓瘤细胞分泌了大量的IgA κ单克隆蛋白，但在使用环磷酰胺和长春新碱治疗后，尽管肿瘤负荷显著增加，这些细胞却被诱导停止分泌单克隆蛋白。使用抗IgA和抗κ单克隆抗体的免疫荧光技术清楚地证明了胞浆内不存在IgA κ。
