Faculty of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel.
Acta Histochem. 2010 Jul;112(4):345-54. doi: 10.1016/j.acthis.2009.02.006. Epub 2009 Mar 25.
Mitochondria-rich cells are an integral component of the epidermis of amphibian skin and play a functional role. Whereas the principal cell compartment of the epithelium is specialized almost exclusively for active uptake of sodium, the mitochondria-rich cells perform other diverse ion-transport functions, including transport of Cl(-), H(+), HCO(3)(-) and organic molecules. These transporting functions differ in different species. Antibodies, such as those directed against band 3, H(+)-ATPase, and also peanut lectin (PNA), bind specifically to the mitochondria-rich cells, but do so differently in various species. Examination of these immunolocalizations and lectin labeling in the skin of over 10 amphibian species, including both Anurans and Urodeles, illustrate species-specific differences. The binding pattern and the transport capabilities of the skin in the various species do not show a universal correlation, they appear to be species specific and do not permit construction of a general scheme common to all the species studied. The mitochondria-rich cells of heterocellular epithelia and their roles in ion transport remain a subject that requires further studies to elucidate their particular functions within the framework of the whole epithelium.
富含线粒体的细胞是两栖动物皮肤表皮的一个组成部分，发挥着重要的功能。表皮的主要细胞隔室几乎专门用于主动摄取钠离子，而富含线粒体的细胞则执行其他不同的离子转运功能，包括 Cl(-)、H(+)、HCO(3}(-)和有机分子的转运。这些转运功能在不同物种中存在差异。抗体，如针对带 3、H(+)-ATP 酶的抗体，以及花生凝集素 (PNA)，特异性地结合到富含线粒体的细胞，但在不同物种中的结合方式不同。对包括无尾目和有尾目在内的 10 多种两栖动物皮肤的这些免疫定位和凝集素标记的检查表明存在物种特异性差异。各种物种的皮肤的免疫结合模式和转运能力没有显示出普遍的相关性，它们似乎是物种特异性的，不允许为所有研究物种构建一个通用的方案。异细胞上皮的富含线粒体的细胞及其在离子转运中的作用仍然是一个需要进一步研究的课题，以阐明它们在整个上皮细胞中的特定功能。
