半乳糖黄素诱导的核黄素缺乏对大鼠肝细胞超微结构的影响。

Effects of galactoflavin-induced riboflavin deficiency upon rat hepatic cell ultrastructure.

作者信息

Norton W N, Daskal I, Savage H E, Seibert R A, Busch H, Lane M

出版信息

Virchows Arch B Cell Pathol. 1977 Apr 15;23(4):353-61. doi: 10.1007/BF02889143.

PMID:193247

Abstract

The primary cytoplasmic effect of galactoflavin-induced riboflavin deficiency upon rat liver cells involved focal sites of degradation which were manifested by the formation of membranous whorls. The nuclear effect of riboflavin deficiency concerned fluctuations in the total number of perichromatin granules per nucleus. These granules increased in number during the deficiency reaching a peak at three weeks. Nucleoli appeared compact with no evidence for segregation of nucleolar components. The possible correlation between increased synthesis of perichromatin granules and altered protein synthesis is discussed.

摘要

半乳黄素诱导的核黄素缺乏对大鼠肝细胞的主要细胞质效应涉及降解的局灶部位，表现为膜性涡旋的形成。核黄素缺乏的核效应涉及每个细胞核中染色质周围颗粒总数的波动。在缺乏期间，这些颗粒数量增加，在三周时达到峰值。核仁显得致密，没有核仁成分分离的迹象。讨论了染色质周围颗粒合成增加与蛋白质合成改变之间可能的相关性。