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核黄素缺乏对大鼠坐骨神经纤维超微结构的影响。

Effects of riboflavin deficiency on the ultrastructure of rat sciatic nerve fibers.

作者信息

Norton W N, Daskal I, Savage H E, Seibert R A, Lane M

出版信息

Am J Pathol. 1976 Dec;85(3):651-60.

PMID:998735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2032662/
Abstract

Ultrastructural studies indicate that riboflavin deficiency induced by either dietary restrictions alone or with the addition of the antagonist galactoflavin severely affects the structural integrity of myelin lamellae. The degenerative process induced by riboflavin deficiency is time dependent. Nonmyelinated nerve fibers are not affected ultrastructurally by the deficiency. Cellular organelles of both myelinated and nonmyelinated nerve fibers remain intact and presumably functional.

摘要

超微结构研究表明，单独通过饮食限制或添加拮抗剂半乳糖黄素诱导的核黄素缺乏会严重影响髓鞘板层的结构完整性。核黄素缺乏诱导的退行性过程是时间依赖性的。无髓神经纤维在超微结构上不受该缺乏症的影响。有髓和无髓神经纤维的细胞器均保持完整且可能具有功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/6479883ea072/amjpathol00445-0142-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/c0dee87e582f/amjpathol00445-0139-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/9f0bdd21b55f/amjpathol00445-0141-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/5b2963761fa1/amjpathol00445-0141-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/99838855811b/amjpathol00445-0141-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/d3f8216977d8/amjpathol00445-0141-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/158e695eb997/amjpathol00445-0142-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/8b1a00deaa6b/amjpathol00445-0142-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/6da7a5009715/amjpathol00445-0142-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/6479883ea072/amjpathol00445-0142-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/c0dee87e582f/amjpathol00445-0139-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/9f0bdd21b55f/amjpathol00445-0141-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/5b2963761fa1/amjpathol00445-0141-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/99838855811b/amjpathol00445-0141-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/d3f8216977d8/amjpathol00445-0141-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/158e695eb997/amjpathol00445-0142-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/8b1a00deaa6b/amjpathol00445-0142-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/6da7a5009715/amjpathol00445-0142-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208c/2032662/6479883ea072/amjpathol00445-0142-d.jpg

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本文引用的文献

1
Some anabolic aspects of protein metabolism in riboflavin deficiency in the rat.大鼠核黄素缺乏时蛋白质代谢的一些合成代谢方面
Br J Nutr. 1960;14:231-8. doi: 10.1079/bjn19600028.
2
THE RAPID INDUCTION OF HUMAN RIBOFLAVIN DEFICIENCY WITH GALACTOFLAVIN.用半乳糖黄素快速诱发人体核黄素缺乏症。
J Clin Invest. 1964 Mar;43(3):357-73. doi: 10.1172/JCI104921.
3
The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.在电子显微镜检查中，将高pH值的柠檬酸铅用作电子不透明染色剂。
J Cell Biol. 1963 Apr;17(1):208-12. doi: 10.1083/jcb.17.1.208.
4
Staining of tissue sections for electron microscopy with heavy metals.用重金属对组织切片进行电子显微镜染色。
J Biophys Biochem Cytol. 1958 Jul 25;4(4):475-8. doi: 10.1083/jcb.4.4.475.
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Metabolism of fatty acids.脂肪酸的代谢
Annu Rev Biochem. 1969;38:159-212. doi: 10.1146/annurev.bi.38.070169.001111.