King K Y, Edwards M S, Word B M
Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA.
J Perinatol. 2009 Apr;29(4):320-2. doi: 10.1038/jp.2008.197.
Micafungin is an echinocandin-class antifungal agent licensed for treatment of invasive disease in adults. The optimal dosing regimens have not been established for infants. We describe a premature infant who developed hepatitis and cholestasis during micafungin therapy initiated for protracted candidemia. Practitioners should be aware of this potential adverse effect if using micafungin in young patients.
米卡芬净是一种棘白菌素类抗真菌药物，已获许可用于治疗成人侵袭性疾病。对于婴儿，尚未确定最佳给药方案。我们描述了一名早产儿，在因持续性念珠菌血症开始使用米卡芬净治疗期间出现了肝炎和胆汁淤积。如果在年轻患者中使用米卡芬净，从业者应意识到这种潜在的不良反应。
