病毒转化与非整倍体
Viral transformation and aneuploidy.
作者信息
Yasunaga Junichiro, Jeang Kuan-Teh
机构信息
Molecular Virology Section, Laboratory of Molecular Microbiology, The National Institute of Allergy and Infectious Diseases/NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA.
出版信息
Environ Mol Mutagen. 2009 Oct;50(8):733-40. doi: 10.1002/em.20480.
Human tumor viruses are associated with a variety of human malignancies, and it is estimated that 15% of all human cancers have a viral etiology. An abnormality in chromosomal ploidy or aneuploidy is a hallmark of cancers. In normal cells, euploidy is governed by several factors including an intact spindle assembly checkpoint, accurate centrosome duplication, and proper cytokinesis. Viral oncoproteins are suggested to perturb the cellular machineries for chromosomal segregation creating aneuploidy which can lead to the malignant transformation of infected cells. Here, we review in brief some of the mechanisms used by viruses that can cause cellular aneuploidy.
人类肿瘤病毒与多种人类恶性肿瘤相关，据估计，所有人类癌症中有15%具有病毒病因。染色体倍性异常或非整倍体是癌症的一个标志。在正常细胞中，整倍体受多种因素控制，包括完整的纺锤体组装检查点、准确的中心体复制和适当的胞质分裂。病毒癌蛋白被认为会干扰细胞的染色体分离机制，导致非整倍体的产生，进而可能导致受感染细胞的恶性转化。在此，我们简要回顾一些可导致细胞非整倍体的病毒所采用的机制。
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