人类 T 细胞白血病病毒 1 型（HTLV-1）和白血病转化：病毒感染力、Tax、HBZ 和治疗。
Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy.
机构信息
Institute for Virus Research, Kyoto University, Kyoto, Japan.
出版信息
Oncogene. 2011 Mar 24;30(12):1379-89. doi: 10.1038/onc.2010.537. Epub 2010 Nov 29.
Abstract
The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic animal retroviruses that transform cells, Tax does not originate from a c-onc counterpart. In this article, we review progress in our understanding of HTLV-1 infectivity, cellular transformation, anti-sense transcription and therapy, 30 years after the original discovery of this virus.
摘要
人类 T 细胞白血病病毒 1 型（HTLV-1）是第一种被发现可导致人类癌症（成人 T 细胞白血病）的逆转录病毒。HTLV-1 的转化实体归因于病毒编码的致癌蛋白 Tax。与其他致癌性动物逆转录病毒编码的 v-onc 蛋白不同，Tax 并非源自 c-onc 对应物。在本文中，我们回顾了 30 年来对该病毒的原始发现后，我们对 HTLV-1 感染性、细胞转化、反义转录和治疗的理解的进展。
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