Schiff Deborah, Kline Cassie, Meltzer Hal, Auger JoAnne
Department of Hematology/Oncology, Rady Children's Hospital-San Diego, San Diego, California 92123, USA.
J Palliat Med. 2009 Apr;12(4):391-3. doi: 10.1089/jpm.2008.0227.
The authors present a case report of a pediatric patient with recurrent metastatic medulloblastoma who demonstrated significant clinical improvement after placement of a palliative ventriculoperitoneal (VP) shunt. They also review the medical literature that supports palliative surgical management of hydrocephalus and intracranial hypertension (ICH) caused by leptomeningeal (LM) spread of malignancy. The burdens and benefits of an invasive surgical procedure must always be weighed carefully, especially at end-of-life. Yet for some patients with LM spread and ICH, VP shunting may improve their quality of life, although their prognosis remains poor.
作者报告了一例复发性转移性髓母细胞瘤的儿科患者病例,该患者在置入姑息性脑室腹腔(VP)分流管后临床症状有显著改善。他们还回顾了支持对因恶性肿瘤软脑膜(LM)播散导致的脑积水和颅内高压(ICH)进行姑息性手术治疗的医学文献。侵入性外科手术的负担和益处必须始终仔细权衡,尤其是在生命末期。然而,对于一些患有LM播散和ICH的患者,VP分流术可能会改善他们的生活质量,尽管其预后仍然很差。