Nuyts Johan, Vunckx Kathleen, Defrise Michel, Vanhove Christian
Nuclear Medicine, Katholieke Universiteit Leuven, UZ Gasthuisberg, Herestraat 49, B3000 Leuven, Belgium.
Methods. 2009 Jun;48(2):83-91. doi: 10.1016/j.ymeth.2009.03.015. Epub 2009 Mar 26.
With Single Photon Emission Computed Tomography (SPECT), images of minute concentrations of tracer molecules can be acquired, allowing in vivo molecular imaging. For human imaging, the SPECT system has a modest spatial resolution of 5-15 mm, a large field of view and a high sensitivity. Using multi-pinhole SPECT, one can trade in field of view for resolution with preserved sensitivity, which enables the implementation of a small animal SPECT system with an improved resolution, currently ranging from 0.3 to 2 mm, in a much smaller field of view. The unconventional collimation and the more stringent resolution requirements pose problems that are not present in clinical SPECT imaging. This paper discusses how these problems can be solved to implement micro-SPECT imaging on a rotating gamma camera.
利用单光子发射计算机断层扫描（SPECT），可以获取微量示踪剂分子的图像，实现体内分子成像。对于人体成像，SPECT系统具有适度的空间分辨率，为5 - 15毫米，视野大且灵敏度高。使用多孔径SPECT，可以在保持灵敏度的情况下，用视野换取分辨率，这使得能够在更小的视野中实现分辨率得到提高的小动物SPECT系统，目前其分辨率范围为0.3至2毫米。非常规准直和更严格的分辨率要求带来了临床SPECT成像中不存在的问题。本文讨论了如何解决这些问题，以便在旋转伽马相机上实现微型SPECT成像。
