Schneeberger S, Gorantla V S, Hautz T, Pulikkottil B, Margreiter R, Lee W P A
Center of Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.
Transplant Proc. 2009 Mar;41(2):472-5. doi: 10.1016/j.transproceed.2009.01.019.
Avoidance or at least minimization of maintenance immunosuppression represents the key step for promoting wider applicability of reconstructive transplantation. Understanding the mechanisms of composite tissue allograft rejection is essential in working toward that goal. We herein review the current knowledge on acute rejection in reconstructive transplantation and discuss findings in the light of novel immunosuppressive and immunomodulatory strategies.
避免或至少尽量减少维持性免疫抑制是促进重建移植更广泛应用的关键步骤。了解复合组织同种异体移植排斥反应的机制对于实现这一目标至关重要。我们在此回顾了重建移植中急性排斥反应的现有知识，并根据新的免疫抑制和免疫调节策略讨论了相关研究结果。
