对基质金属蛋白酶家族的分析表明，MMP8在黑色素瘤中常常发生突变。
Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.
作者信息
Palavalli Lavanya H, Prickett Todd D, Wunderlich John R, Wei Xiaomu, Burrell Allison S, Porter-Gill Patricia, Davis Sean, Wang Chenwei, Cronin Julia C, Agrawal Neena S, Lin Jimmy C, Westbroek Wendy, Hoogstraten-Miller Shelley, Molinolo Alfredo A, Fetsch Patricia, Filie Armando C, O'Connell Michael P, Banister Carolyn E, Howard Jason D, Buckhaults Phillip, Weeraratna Ashani T, Brody Lawrence C, Rosenberg Steven A, Samuels Yardena
机构信息
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
Nat Genet. 2009 May;41(5):518-20. doi: 10.1038/ng.340. Epub 2009 Mar 29.
Abstract
A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild-type MMP-8 has the ability to inhibit melanoma progression.
摘要
一项对人类黑色素瘤中基质金属蛋白酶（MMP）基因家族的突变分析发现，23%的黑色素瘤存在体细胞突变。在最常发生突变的基因之一MMP8中，有五个突变降低了MMP酶的活性。在人类黑色素瘤细胞中表达野生型而非突变型MMP8可抑制体外软琼脂上的生长和体内肿瘤形成，这表明野生型MMP-8具有抑制黑色素瘤进展的能力。
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