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Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.对基质金属蛋白酶家族的分析表明，MMP8在黑色素瘤中常常发生突变。
Nat Genet. 2009 May;41(5):518-20. doi: 10.1038/ng.340. Epub 2009 Mar 29.
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Wild-type versus mutant MMP-8 in melanoma: 'when you come to a fork in the road, take it'.黑色素瘤中野生型与突变型基质金属蛋白酶-8：“当你走到岔路口时，就选择它”。
Pigment Cell Melanoma Res. 2009 Jun;22(3):248-50. doi: 10.1111/j.1755-148X.2009.00573.x. Epub 2009 Apr 15.
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Analysis of Enzymatic Activity of Matrix Metalloproteinase (MMP) by Collagen Zymography in Melanoma.黑色素瘤中利用胶原蛋白酶谱分析法分析基质金属蛋白酶（MMP）的酶活性
Methods Mol Biol. 2018;1731:97-106. doi: 10.1007/978-1-4939-7595-2_10.
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Protective roles of matrix metalloproteinases: from mouse models to human cancer.基质金属蛋白酶的保护作用：从鼠模型到人癌症。
Cell Cycle. 2009 Nov 15;8(22):3657-62. doi: 10.4161/cc.8.22.9956. Epub 2009 Dec 1.
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Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.肿瘤抑制和转移抑制基质金属蛋白酶-8在MMTV-PyMT转基因小鼠乳腺癌中的多效性功能
Breast Cancer Res. 2015 Mar 14;17(1):38. doi: 10.1186/s13058-015-0545-8.
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Neutrophil collagenase (MMP-8) is expressed during early development in neural crest cells as well as in adult melanoma cells.中性粒细胞胶原酶（基质金属蛋白酶-8）在神经嵴细胞的早期发育过程以及成年黑色素瘤细胞中均有表达。
Matrix Biol. 2001 Dec;20(8):577-87. doi: 10.1016/s0945-053x(01)00166-4.
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A Novel Role of Matrix Metalloproteinase-8 in Macrophage Differentiation and Polarization.基质金属蛋白酶-8在巨噬细胞分化和极化中的新作用
J Biol Chem. 2015 Jul 31;290(31):19158-72. doi: 10.1074/jbc.M114.634022. Epub 2015 Jun 19.
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An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo.基质金属蛋白酶-8 在体外和体内血管生成中的重要作用。
Cardiovasc Res. 2013 Jul 1;99(1):146-55. doi: 10.1093/cvr/cvt060. Epub 2013 Mar 19.
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Association of MMP8 gene variation with an increased risk of malignant melanoma.MMP8 基因变异与恶性黑色素瘤风险增加相关。
Melanoma Res. 2011 Oct;21(5):464-8. doi: 10.1097/CMR.0b013e3283485fdd.
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Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation.基质金属蛋白酶-8 促进血管平滑肌细胞增殖和新生内膜形成。
Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):90-8. doi: 10.1161/ATVBAHA.113.301418. Epub 2013 Oct 24.
引用本文的文献
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The adhesion-GPCR ADGRF5 fuels breast cancer progression by suppressing the MMP8-mediated antitumorigenic effects.黏附 G 蛋白偶联受体 ADGRF5 通过抑制 MMP8 介导的抗肿瘤作用促进乳腺癌进展。
Cell Death Dis. 2024 Jun 27;15(6):455. doi: 10.1038/s41419-024-06855-8.
2
Identification of potential immune-related mechanisms related to the development of multiple myeloma.鉴定与多发性骨髓瘤发展相关的潜在免疫相关机制。
Chin Med J (Engl). 2024 Jul 5;137(13):1603-1613. doi: 10.1097/CM9.0000000000003116. Epub 2024 Jun 6.
3
Understanding the matrix: collagen modifications in tumors and their implications for immunotherapy.了解基质：肿瘤中的胶原蛋白修饰及其对免疫治疗的影响。
J Transl Med. 2024 Apr 24;22(1):382. doi: 10.1186/s12967-024-05199-3.
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Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myeloma through single-cell sequencing.通过单细胞测序鉴定复发/难治性多发性骨髓瘤中BCMA嵌合抗原受体T细胞（CAR-T）疗法复发的潜在耐药机制和治疗靶点。
Exp Hematol Oncol. 2023 May 8;12(1):44. doi: 10.1186/s40164-023-00402-5.
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The immunomodulatory role of matrix metalloproteinases in colitis-associated cancer.基质金属蛋白酶在结肠炎相关癌症中的免疫调节作用。
Front Immunol. 2023 Jan 19;13:1093990. doi: 10.3389/fimmu.2022.1093990. eCollection 2022.
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Loss of MMP-27 Predicts Mandibular Bone Invasion in Oral Squamous Cell Carcinoma.基质金属蛋白酶-27的缺失预示口腔鳞状细胞癌的下颌骨侵犯。
Cancers (Basel). 2022 Aug 22;14(16):4044. doi: 10.3390/cancers14164044.
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Analysis of and somatic mutations in differentiated thyroid cancers.分化型甲状腺癌中的 和 体细胞突变分析。 （你提供的原文中“Analysis of and somatic mutations”这里两个“and”之间内容缺失，以上是按现有内容翻译）
Mol Clin Oncol. 2021 Oct;15(4):210. doi: 10.3892/mco.2021.2373. Epub 2021 Aug 10.
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A Transcriptome-Wide Isoform Landscape of Melanocytic Nevi and Primary Melanomas Identifies Gene Isoforms Associated with Malignancy.黑素细胞痣和原发性黑素瘤的转录组全长异构体景观鉴定出与恶性肿瘤相关的基因异构体。
Int J Mol Sci. 2021 Jul 2;22(13):7165. doi: 10.3390/ijms22137165.
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Mutational drivers of cancer cell migration and invasion.癌症细胞迁移和侵袭的突变驱动因素。
Br J Cancer. 2021 Jan;124(1):102-114. doi: 10.1038/s41416-020-01149-0. Epub 2020 Nov 18.
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Hinokiflavone induces apoptosis and inhibits migration of breast cancer cells via EMT signalling pathway.蛇床素通过 EMT 信号通路诱导乳腺癌细胞凋亡并抑制其迁移。
Cell Biochem Funct. 2020 Apr;38(3):249-256. doi: 10.1002/cbf.3443. Epub 2020 Feb 27.
本文引用的文献
1
Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.基质金属蛋白酶-8通过调节肿瘤细胞的黏附和侵袭发挥转移抑制作用。
Cancer Res. 2008 Apr 15;68(8):2755-63. doi: 10.1158/0008-5472.CAN-07-5154.
2
Emerging roles of proteases in tumour suppression.蛋白酶在肿瘤抑制中的新作用。
Nat Rev Cancer. 2007 Oct;7(10):800-8. doi: 10.1038/nrc2228.
3
Patterns of somatic mutation in human cancer genomes.人类癌症基因组中的体细胞突变模式。
Nature. 2007 Mar 8;446(7132):153-8. doi: 10.1038/nature05610.
4
The consensus coding sequences of human breast and colorectal cancers.人类乳腺癌和结直肠癌的共有编码序列。
Science. 2006 Oct 13;314(5797):268-74. doi: 10.1126/science.1133427. Epub 2006 Sep 7.
5
Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer.使用定制的双物种微阵列分析宿主和肿瘤来源的蛋白酶揭示了基质金属蛋白酶-12在非小细胞肺癌中的保护作用。
Cancer Res. 2006 Aug 15;66(16):7968-75. doi: 10.1158/0008-5472.CAN-05-4279.
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The melanocyte differentiation program predisposes to metastasis after neoplastic transformation.黑素细胞分化程序使肿瘤转化后易于发生转移。
Nat Genet. 2005 Oct;37(10):1047-54. doi: 10.1038/ng1634. Epub 2005 Sep 4.
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Altered metastatic behavior of human breast cancer cells after experimental manipulation of matrix metalloproteinase 8 gene expression.实验性调控基质金属蛋白酶8基因表达后人类乳腺癌细胞转移行为的改变
Cancer Res. 2004 Mar 1;64(5):1687-94. doi: 10.1158/0008-5472.can-03-2047.
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Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.胶原酶-2缺失使雄性小鼠对皮肤肿瘤的易感性增加。
Nat Genet. 2003 Nov;35(3):252-7. doi: 10.1038/ng1249. Epub 2003 Sep 28.
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Matrix metalloproteinases and tumor progression.基质金属蛋白酶与肿瘤进展
Adv Exp Med Biol. 2003;532:91-107. doi: 10.1007/978-1-4615-0081-0_9.
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Matrix metalloproteinases: a tail of a frog that became a prince.基质金属蛋白酶：一只变成王子的青蛙的尾巴。
Nat Rev Mol Cell Biol. 2002 Mar;3(3):207-14. doi: 10.1038/nrm763.
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