Petersen E E
Z Hautkr. 1977 Apr 1;52(7):417-26.
The part of the herpes simplex virus type 2 in the development of the cervex carcinoma of women is still an open question. After the serological findings that patients with cervix carcinoma have a higher rate of antibodies against type 2 than healthy women, which were initially published with great expectation, the molecular-virological examinations which were meanwhile carried out by several work groups to find traces of the herpes simplex virus type 2 in the carcinoma cells were negative, except some few but not confirmed cases. Hitherto but the results of transformation of embryonic hamster cells by UV-inactivated virus were the strongest indication for the herpes simplex virus possibly having oncogenic power, although one of the most important demonstrations, i.e. that of the virus DNA, is still lacking even for these transformed cells, which induce fibrosarcoma if injected to newborn hamsters. Possibly the transformation of the normal hamster cell into a tumor cell requires but such a small quantity of the herpes simplex virus DNA that it cannot be traced with the present methods. In connection with the question of the herpes simplex virus being oncogenic also LUPIDON which contains heat-inactivated herpes simplex virus, was examined. For this purpose extended transformation experiments in vitro and animal experiments with new-born hamsters were carried out. All these experiments had a negative result. There is thus no indication for LUPIDON having oncogenic properties.
单纯疱疹病毒2型在女性宫颈癌发生过程中所起的作用仍是一个悬而未决的问题。血清学研究发现，宫颈癌患者体内抗2型病毒抗体的比例高于健康女性，这一最初被寄予厚望的发现公布后，多个研究小组随后开展了分子病毒学检查，试图在癌细胞中找到单纯疱疹病毒2型的踪迹，但结果均为阴性，仅有少数几例未经证实。迄今为止，紫外线灭活病毒转化胚胎仓鼠细胞的结果是单纯疱疹病毒可能具有致癌能力的最有力证据，不过，即便对于这些转化细胞（若注射到新生仓鼠体内会诱发纤维肉瘤）而言，最重要的证据之一，即病毒DNA的证据，仍然缺失。正常仓鼠细胞转化为肿瘤细胞或许只需极少量的单纯疱疹病毒DNA，以至于用现有方法无法追踪到。关于单纯疱疹病毒具有致癌性的问题，还对含有热灭活单纯疱疹病毒的LUPIDON进行了研究。为此，开展了体外长期转化实验以及针对新生仓鼠的动物实验。所有这些实验结果均为阴性。因此，没有迹象表明LUPIDON具有致癌特性。
