Schneweis K E
Z Hautkr. 1977 Apr 1;52(7):427-32.
The epidemiological principle of the herpes simplex virus (HSV) infections is to have the affected host survive, to persist in it and thus to make it to be a life long starting point for new infection chains. There is an accurately tuned correlation between virus and host organism, in which the persistence of the virus as a latent infection in the ganglion cells of sensory neurones is of central importance. In this state the virus cannot be attacked by the defensive power of the body. When changing from latency in the ganglion cell to activity in the periphery it utilizes the nerve conduction. It has not yet been cleared which factors are responsible for the change-over from the productive, cytocide infection to the latent infection, how the latency is being stabilized and how the reactivation to the herpes recidivans takes place. The organ and tissue specifity of both the HSV types 1 and 2 seems to be bound to the entire pathogenetic complex so that inspite of occasional reverse infections HSV type 1 remains epidemiologically the facial virus type and HSV type 2 the genital one. Apparent and inapparent rimary infections and relapes lead to numerous uncontrolled contacts so that the rate of infection is 50% until the age of puberty and 80% in middle-age adults. The contamination with the mainly venerically transmitted HSV type 2 starts with the age of puberty and reaches abt. 10 to 15% of our population. In patients suffering from cervix carcinoma antibodies against herpes simplex virus type 2 are more frequently demonstrated. Comparative examinations have shown that an increased exposition cannot be the sole cause for this prevalence. The kind of relationship between herpes genitalis and cervix carcinoma remains, however, unclear.
单纯疱疹病毒（HSV）感染的流行病学原理是使受感染宿主存活，在宿主体内持续存在，从而使其成为新感染链的终生起始点。病毒与宿主生物体之间存在精确调节的相关性，其中病毒作为潜伏感染存在于感觉神经元的神经节细胞中至关重要。在这种状态下，病毒无法受到机体防御能力的攻击。当从神经节细胞中的潜伏状态转变为外周的活跃状态时，它利用神经传导。目前尚不清楚哪些因素导致从增殖性、细胞杀伤性感染转变为潜伏感染，潜伏状态如何稳定以及疱疹复发的重新激活是如何发生的。HSV-1和HSV-2两种类型的器官和组织特异性似乎与整个致病复合体相关，因此尽管偶尔会有反向感染，HSV-1在流行病学上仍是面部病毒类型，HSV-2仍是生殖器病毒类型。显性和隐性原发性感染及复发导致大量未受控制的接触，因此在青春期前感染率为50%，中年成年人中为80%。主要通过性传播的HSV-2的感染从青春期开始，在我们的人群中约占10%至15%。在宫颈癌患者中，更频繁地检测到抗单纯疱疹病毒2型的抗体。比较检查表明，接触增加并非这种患病率高的唯一原因。然而，生殖器疱疹与宫颈癌之间的关系仍不清楚。
